Metabolomic Pathways and Traditional Chinese Medicine Body Constitution in Cancer-related Fatigue

The aim of this study is to integrate insights from metabolomics and TCMBC to identify biomarkers and physiological pathways associated with CRF.

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Key information

Conditions

Colorectal Cancer Colonic Diseases Colorectal Neoplasms Digestive System Diseases Digestive System Neoplasms Gastrointestinal Diseases Gastrointestinal Neoplasms Intestinal Diseases Intestinal Neoplasms Neoplasms Neoplasms by Site Rectal Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Patients aged 18 years or older
Diagnosed with stage I to III CRC and scheduled for surgical treatment
Cognitively intact and able to communicate in either Mandarin or Taiwanese
Willing to participate in the study and provide written informed consent.

Exclusion criteria

Patients diagnosed with stage IV colorectal cancer
Patients with recurrent colorectal cancer or other concurrent cancers.

Treatment and study plan

Primary outcomes

Self-report Questionnaire

Time frame: Change from baseline to 3 months after surgery.

The study utilizes two instruments. First, the Fatigue Symptom Inventory (FSI) is used to assess fatigue; total scores range from 0 to 127, with higher scores indicating greater fatigue severity. Second, the Body Constitution Questionnaire (BCQ) comprises 16 items, with total scores ranging from 16 to 80.

Study contacts

Contact information is provided by the study sponsor or research team.

Yun-Jen Chou, PhD

CONTACT

[email protected]

886-3-2118800 ext. 3512

Sponsors and collaborators

Lead sponsor

Chang Gung Memorial Hospital

Other

Registry information

Official study title

The Exploration of the Relationship Between Metabolomic Pathways and Traditional Chinese Medicine Body Constitution in Cancer-related Fatigue in Patients With Colorectal Cancer

Important dates

Study start: 2026
Primary completion: 2028
Study completion: 2029
First posted: Mar 24, 2026
Registry last updated: Mar 27, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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