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Completed

NCT Number: NCT02957188

Metabolism of Omega-3 and Omega-6 During Healthy Aging

The purpose of this study is to determine the kinetics of 13C-eicosapentaenoic acid (EPA) and 13C-arachidonic acid (AA) in young and older participants

Completed

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Key information

Conditions

Healthy Volunteers

Age range

18 year and older

Sex eligibility

Male

Study type

Observational

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • six young (18-30 y old) and six older (≥ 70 y old)
  • healthy non medicated participants.

Exclusion criteria

  • Tobacco,
  • malnutrition (assessed from blood albumin, haemoglobin and lipids), -
  • participants taking an EPA+DHA supplements or consuming more than 2 fish meals per week,
  • severe gastro-intestinal problems,
  • medication for diabetes,
  • thyroid disease,
  • renal failure,
  • cancer,
  • psychiatric difficulties or depression,
  • cardiovascular disease,
  • glucose intolerance (>8 mmol/L in fasted samples)
  • chronic immune condition or inflammation (CRP > 10 mg/l, white cell count),
  • recent major surgery or cardiac event,
  • dementia,
  • ongoing or past severe drug or alcohol abuse,
  • ongoing or past intensive physical training.

Treatment and study plan

13C eicosapentaenoic acid and 13C arachidonic acid

Other

Each participant orally consumed a single oral dose of 35 mg of 13C-EPA, and after the wash-out, a 50 mg dose of 13C-AA.

Primary outcomes

  1. Kinetics of 13C-EPA and 13C-AA

    Time frame: Plasma incorporation of 13C-EPA or 13C-AA was measured from the area under the curve in young and older participants over 28 days post-dose

Sponsors and collaborators

Lead sponsor

Université de Sherbrooke

Other

Collaborators

  • Healthy Aging Research Network

Registry information

Official study title

Metabolism of Uniformly Labelled 13C Eicosapentaenoic Acid and 13C Arachidonic Acid During Healthy Aging

Important dates

Study start
2015
Primary completion
2016
Study completion
2016
First posted
Nov 7, 2016
Registry last updated
Nov 7, 2016

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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