Metabolism and Sleep Apnea Treatment

Aim 1 Group:

Inclusion criteria

• Age between 18-70 years
• Ability to provide consent

Exclusion criteria

• Body Mass Index (BMI) > 40 kg/m2
• Prevalent myocardial infarction, coronary revascularization, heart failure, and stroke
• Type 1 or Type 2 diabetes mellitus
• Current or prior use of PAP or oral appliance therapy for OSA
• Use of oral corticosteroids
• Unstable medical conditions that may preclude enrollment in the protocol such as: uncontrolled angina and/or congestive heart failure, uncontrolled blood pressure or resistant hypertension, severe chronic obstructive pulmonary disease, cancer, and active psychiatric disease (e.g., major depression)
• Other sleep disorders (e.g., circadian rhythm disorder, self-reported habitual sleep duration < 6h)
• Use of supplemental oxygen during wakefulness or sleep
• Central sleep apnea, obesity hypoventilation syndrome or Cheyne-Stokes respiration based on the home sleep test
• Resting awake Oxygen Saturation (SpO2) < 90%

Aim 2 Group:

Inclusion criteria

• Age between 18-70 years
• Ability to provide consent
• Moderate-to-severe OSA (AHI ≥ 15/h);
• Demonstration of Positive Airway Pressure (PAP) use of > 4 h/night on 70% of the nights during 1-week run-in period
• Successful completion of all of the procedures for Aim 1.

Exclusion criteria

• BMI: ≥ 40 kg/m2
• Type 1 or Type 2 diabetes mellitus
• Current use of PAP or oral appliance therapy for OSA
• Commercial driver or report of motor vehicle accident or near-miss due to sleepiness within the 2 previous years
• Epworth sleepiness score of 18 or more
• Use of oral corticosteroids
• Participation in another clinical trial
• Unstable medical conditions that may preclude enrollment in the protocol such as: uncontrolled angina and/or congestive heart failure, uncontrolled blood pressure or resistant hypertension, severe chronic obstructive pulmonary disease, cancer, and active psychiatric disease (e.g., major depression)
• Other sleep disorders (e.g., circadian rhythm disorder, self-reported habitual sleep duration < 6h)
• Use of supplemental oxygen during wakefulness or sleep
• Central sleep apnea, obesity hypoventilation syndrome or Cheyne-Stokes respiration based on the home sleep test
• Resting awake SpO2 < 90%