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Completed

NCT Number: NCT01974947

Metabolic Syndrome and Male Infertility

Multidisciplinary, multicentric, cross-sectional study on men in infertile couples who conduct their sperm test through their diagnosis of infertility

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Key information

Conditions

Male Infertility Genital Diseases Genital Diseases, Male Glucose Metabolism Disorders Hyperinsulinism Infertility Infertility, Male Insulin Resistance Male Urogenital Diseases Metabolic Diseases Metabolic Syndrome Nutritional and Metabolic Diseases Urogenital Diseases

Age range

18 year–45 year

Sex eligibility

Male

Study type

Observational

Primary location

Jean Verdier Hospital

Bondy, 93140, France

About this study

Assessment of sperm parameters and metabolic syndrome relations in men attending a Reproductive Biomedicine centre for an infertility of their couple.

Secondary objectives are to study relationship between sperm parameters and:

  • adiposity and insulin resistance
  • inflammation
  • oxydative stress in blood and semen
  • hormonal status Innovative parameters will also be assessed to determine the quality of semen (length of fingers, wrist circumference and epigenetics studies)

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • 18 to 45 years-old man
  • man consulting for primary or secondary infertility, with or without earlier notion of paternity
  • patient insured with a social security scheme
  • patient who have had a prior medical consultation
  • patient who have done informed and written consent to participate in the research study

Exclusion criteria

  • patient with problems understanding French
  • patient smoking more than two-pack-a-day
  • patient monitoring for viral risk.
  • man with an unidiopathic infertility which may be explained by:
  • identifiable factors in direct questioning at the sperm analysis:
  • exposure to toxic products
  • infectious disease history
  • pathological anatomical background 2) factors identified at the etiologic investigation: cytogenetic and genetic

Treatment and study plan

Blood sample, sperm sample and clinical examens

Other

Blood sample, sperm sample and clinical examens will be done at the day of the inclusion

Primary outcomes

  1. Number of spermatozoid and their relation with syndrome metabolic parameters

    Time frame: Day 0

    We will measure the parameters of metabolic syndrome (triglycerides, HDL and LDL cholesterol, systolic and diastolic blood pressure, fasting glucose) and correlate them with the number of spermatozoid .

Secondary outcomes

  1. Relationship between spermogram and spermocytogram and other metabolic parameters

    Time frame: Day 0

    Relationship between other spermogram/spermocytogram and metabolic markers (biomarkers and anthropometric adiposity and insulin resistance)

  2. Environmental parameters

    Time frame: Day 0

    Evaluation of environmental parameters (physical activity, tobacco consumption, quality of life) by classical questionnaire

  3. Relationship between spermogram and spermocytogram and other metabolic parameters

    Time frame: Day 0

    Relationship between other spermogram/spermocytogram and markers of inflammation

  4. Relationship between spermogram and spermocytogram and other metabolic parameters

    Time frame: Day 0

    Relationship between other spermogram/spermocytogram and markers of oxidative stress (plasma, seminal genetic polymorphisms involved in oxidative stress, genetic analyzes of sperm)

  5. Relationship between spermogram and spermocytogram and other metabolic parameters

    Time frame: Day 0

    Relationship between other spermogram/spermocytogram and hormonal markers

  6. Relationship between spermogram and spermocytogram and other metabolic parameters

    Time frame: Day 0

    Relationship between other spermogram/spermocytogram and innovative settings (studies epigenetic finger length and width of the wrist)

Sponsors and collaborators

Lead sponsor

Assistance Publique - Hôpitaux de Paris

Other

Collaborators

  • URC-CIC Paris Descartes Necker Cochin

Registry information

Official study title

Relationship Between Sperm Parameters and Metabolic Syndrome in a Infertile Couple Partner Man

Acronym: Metasperme

Important dates

Study start
2013
Primary completion
2016
Study completion
2016
First posted
Nov 4, 2013
Registry last updated
Nov 20, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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