Metabolic Response to Food in Lung Cancer

This goal of this study is to describe how unintentional weight loss influences fasting and post-prandial metabolic flexibility in participants with advanced non-small cell lung cancer.

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This study is active but is not currently recruiting participants.

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Key information

Conditions

Carcinoma, Non-Small-Cell Lung Bronchial Neoplasms Carcinoma, Bronchogenic Lung Diseases Lung Neoplasms Neoplasms Neoplasms by Site Respiratory Tract Diseases Respiratory Tract Neoplasms Thoracic Neoplasms

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Pennington Biomedical Research Center

Baton Rouge, Louisiana, 70808, United States

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Age greater than or equal to 18 years
Diagnosis of non-small-cell lung cancer
Reported weight stability or loss after cancer diagnosis
Body mass index less than or equal to 35 kilograms per meter squared
Ability to provide written informed consent
Willing and able to comply with all scheduled visits, treatment plans, lab tests, and other study procedure
Allow the collection and storage of biospecimens and data for future use

Exclusion criteria

Prior diagnosis of diabetes mellitus (type 1 or type 2)
Currently pregnant or breastfeeding
Contraindication to consuming the liquid mixed meal
Any medications affecting gastric motility
Any other condition that, in the investigator's opinion, would preclude participation or successful compliance with the protocol

Treatment and study plan

Weight loss (%)

Other

Change in body weight from cancer diagnosis to study enrollment

Primary outcomes

Respiratory quotient

Time frame: Difference between pre- to post-prandial conditions over four hours

The respiratory quotient will be measured by indirect calorimetry before and after consumption of a liquid mixed meal

Sponsors and collaborators

Lead sponsor

Pennington Biomedical Research Center

Other

Registry information

Acronym: METRIC

Important dates

Study start: 2023
Primary completion: 2026
Study completion: 2026
First posted: Jul 10, 2023
Registry last updated: Jul 4, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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