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OpenTrials
Completed

NCT Number: NCT01469104

Metabolic Response to 3-day Fast Versus Carbohydrate-free Diet in Type 2 Diabetes

The investigators hypothesis is that a carbohydrate-free diet, ingested for 3 days, results in a change in blood glucose that is similar to the change observed after 3 days of fasting.

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Key information

Conditions

Type 2 Diabetes Diabetes Mellitus Diabetes Mellitus, Type 2 Endocrine System Diseases Glucose Metabolism Disorders Metabolic Diseases Nutritional and Metabolic Diseases

Age range

45 year–75 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Minneapolis VA Health Care System

Minneapolis, Minnesota, 55417, United States

About this study

In addition to plasma glucose concentrations, other hormones and metabolites known to be affected by fasting will be measured. These include insulin and glucagon, which are hormones that have an important role in regulating fuel use in the body.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Type 2 diabetes
  • C-peptide > 1.5 ng/ml

Exclusion criteria

  • Body mass index > 40
  • hematological abnormalities
  • liver disease
  • kidney disease
  • congestive heart failure
  • life threatening malignancies

Treatment and study plan

3 day fast

Other

Subjects will fast for 72 hours

Other names: 3-Day Fast

3 day CHO-free diet

Other

Subjects will receive a carbohydrate-free diet for 72 hours

Other names: Carbohydrate-free diet

Primary outcomes

  1. Change in plasma glucose concentration

    Time frame: 24 hour profile:before and after meals, or traditional meal times

Secondary outcomes

  1. Change in serum insulin concentrations

    Time frame: 24 hour profiles: before and after meals or traditional meal times

Sponsors and collaborators

Lead sponsor

Minneapolis Veterans Affairs Medical Center

Fed

Registry information

Acronym: CHO-free diet

Important dates

Study start
2009
Primary completion
2010
Study completion
2010
First posted
Nov 10, 2011
Registry last updated
Nov 10, 2011

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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