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Completed

NCT Number: NCT07538661

Metabolic Regeneration Registry for Periodontal Health (20-Patient Cohort).

This observational study documents the clinical outcomes of a proprietary, safe-to-swallow metabolic protocol for chronic gum disease. Based on 21 years of research and a focused 20-patient cohort, the study records visible clinical improvements in gingival inflammation and tissue color within 7 to 14 days. The protocol focuses on restoring the metabolic environment to achieve non-surgical periodontal pocket stabilization and natural tissue re-attachment.

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Key information

Conditions

Chronic Periodontitis Chronic Disease Chronic Periodontitis Wth Diabetes Mellitus Disease Attributes Gingival Regeneration Metabolic Repair Mouth Diseases Non-surgical Periodontal Treatment Pathologic Processes Pathological Conditions, Signs and Symptoms Periodontal Diseases Periodontitis Stomatognathic Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Zireg

Bordj Bou Arreridj, Wilaya de Bordj Bou Arréridj, 34000, Algeria

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patients (18-75) with documented chronic periodontitis and pocket depths >4mm.

Exclusion criteria

  • Active oral malignancy or pregnancy

Treatment and study plan

Nutraceutical Bio-Active Oral Repair Formula (Food-Grade)

Dietary Supplement

Topical application of a proprietary, 100% food-grade (GRAS) nutraceutical formulation specifically designed for rapid gingival tissue regeneration and inflammation reversal.

Key Performance Indicators:

Speed: Clinical onset of action visible within 3 days. Safety: Completely safe for ingestion (edible), eliminating common side effects of chemical antiseptics like staining or taste alteration.

Efficacy: Significant reduction in redness and bleeding (BOP) within 7 to 14 days, as demonstrated in our cohort of 20+ subjects.

Mechanism: Supports the natural healing of the gum 'peau' (epithelium) through host-response modulation rather than harsh disinfection.

Nutraceutical Bio-Active Oral Repair Formula

Dietary Supplement

Topical application of a proprietary, 100% food-grade (GRAS) nutraceutical formulation specifically designed for rapid gingival tissue regeneration and inflammation reversal.Key Performance Indicators:

Speed: Clinical onset of action visible within 3 days. Safety: Completely safe for ingestion (edible), eliminating common side effects of chemical antiseptics like staining or taste alteration.

Efficacy: Significant reduction in redness and bleeding (BOP) within 7 to 14 days, as demonstrated in our cohort of 20+ subjects.

Mechanism: Supports the natural healing of the gum 'peau' (epithelium) through host-response modulation rather than harsh disinfection."

Primary outcomes

  1. Visible reduction in gingival inflammation and erythema (redness) observed within 7 to 14 days

    Time frame: 7 to 14 days

Secondary outcomes

  1. Measurement of periodontal pocket depth reduction and tissue stability at 6 weeks

    Time frame: 6 weeks

Sponsors and collaborators

Lead sponsor

Amar h Zireg

Other

Collaborators

  • Self funded

Registry information

Official study title

Retrospective Longitudinal Observation of a Proprietary Metabolic Protocol for Rapid Gingival Tissue Repair and Periodontal Pocket Stabilization.

Important dates

Study start
2026
Primary completion
2026
Study completion
2026
First posted
Apr 20, 2026
Registry last updated
Apr 28, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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