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NCT Number: NCT05246813

Metabolic Profiling of Hematopoietic Stem Cells in Clonal Hematopoiesis (CHIP)

Bone marrow samples will be collected from patients undergoing hip arthroplasty surgery. Blood and bone marrow samples will be used for metabolic profiling and analysis of relevant CHIP mutations. Combined single-cell transcriptomics and mutation-specific single-cell genotyping (biotin-PCR using mutation-targeted primers followed by sequencing) will subsequently be performed. The gene expression profile of wildtype and mutant hematopoietic stem cells will be compared, performing both broad gene set enrichment analysis and targeted analysis of metabolic pathways.

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Key information

Conditions

Osteoporosis Aging Arthritis Bone Diseases Bone Diseases, Metabolic Clonal Hematopoiesis of Indeterminate Potential Femoral Fractures Fractures, Bone Hip Fractures Hip Injuries Joint Diseases Leg Injuries Metabolic Diseases Musculoskeletal Diseases Nutritional and Metabolic Diseases Osteoarthritis Osteoarthritis, Hip Rheumatic Diseases Wounds and Injuries

Age range

55 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Imelda Hospital

Bonheiden, België, 2820, Belgium

Location status: Recruiting

Location contact

Hans Casteur, MD

SUB_INVESTIGATOR

Michaël R. Laurent, MD PhD

CONTACT

[email protected]

+32485143267

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Age 65 years and older

Exclusion criteria

  • known haematological condition (myelodysplasia, leukemia, cancer)
  • inability to provide written informed consent

Treatment and study plan

Blood and bone marrow cell collection

Other

Collection of blood and bone marrow

Primary outcomes

  1. Gene Set Enrichment Analysis (GSEA) Normalized Enrichment Score (NES)

    Time frame: One day

Study contacts

Contact information is provided by the study sponsor or research team.

Michaël R. Laurent, MD PhD

CONTACT

[email protected]

+32485143267

Sponsors and collaborators

Lead sponsor

Imelda Hospital, Bonheiden

Other

Collaborators

  • Université Catholique de Louvain

Registry information

Official study title

Metabolic Profiling of Hematopoietic Stem Cells in Clonal Hematopoiesis (CHIP): a Prospective Observational Study

Important dates

Study start
2022
Primary completion
2028
Study completion
2030
First posted
Feb 18, 2022
Registry last updated
Mar 25, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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