Metabolic Phenotypes in Childhood Obesity

This study provides a sound basis towards a better understanding of the biochemical mechanisms behind childhood obesity and its metabolic phenotypes, which will be of great importance towards the development of more personalized prevention and treatment in future.

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Key information

Conditions

Obesity, Pediatric Body Weight Glucose Metabolism Disorders Hyperinsulinism Insulin Resistance Metabolic Diseases Metabolic Syndrome Nutrition Disorders Nutritional and Metabolic Diseases Obesity Overnutrition Overweight Pathological Conditions, Signs and Symptoms Pediatric Obesity Signs and Symptoms

Age range

8 year–18 year

Sex eligibility

All sexes

Study type

Observational

About this study

The aim of this study was to identify the plasma metabolic profile associated with childhood obesity and its phenotypes..

This cross-sectional study was set-up to examine the metabolic profile in fasting plasma samples from 65 overweight and obese (OB) children and 37 normal-weight (NW) controls aged 8 to 18 years. The obtained plasma 1H-NMR spectra were rationally divided into 110 integration regions, representing the metabolic phenotype. These integration regions reflect the relative metabolite concentrations and were used as statistical variables to construct a classification model in discriminating between OB and NW children and adolescents. In addition, two metabolic phenotypes were defined within the OB group, i.e. the metabolically "healthy" obese (MHO) and metabolically unhealthy obese (MUO) phenotype which are both classified as obese but with respectively, none (MHO) or at least two components (MUO) of the metabolic syndrome.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

aged 8 to 18
normal-weight, overweight or obese according to the International Obesity Task Force (IOTF) Body Mass Index (BMI) criteria
fasted for at least 8 hours

Exclusion criteria

Subjects taking any medication or having serious chronic or acute illness within two weeks preceding the clinical examination,

Treatment and study plan

Blood sampling

Other

Determine the metabolic phenotype of blood plasma by proton-NMR spectroscopy

Primary outcomes

metabolic phenotype of childhood obesity

Time frame: day 1

Significant metabolic changes in blood plasma of obese children and adolescents and normal-weight control subjects

Secondary outcomes

metabolic phenotype of metabolically healthy and unhealthy obese children and adolescents

Time frame: day 1

Significant metabolic changes in blood plasma of metabolically healthy obese and metabolically unhealthy obese children and adolescents

Sponsors and collaborators

Lead sponsor

Hasselt University

Other

Collaborators

Jessa Hospital

Registry information

Official study title

Identification of Metabolic Phenotypes in Childhood Obesity by 1H-NMR Metabolomics of Blood Plasma

Important dates

Study start: 2012
Primary completion: 2013
Study completion: 2014
First posted: Jan 9, 2017
Registry last updated: Jan 9, 2017

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed