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NCT Number: NCT02362685

Metabolic Exercise Testing

Exertional symptoms are the hallmarks of metabolic myopathies, supporting the concept of using functional tests when this diagnosis is suspected. Exercise increases the concentration of muscle metabolites in the venous blood supply (e.g. lactate, pyruvate, and ammonia) especially during recovery. The purpose of this study is to compare the results of exercise testing with to the data from muscle biopsy or genetic analysis.

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Key information

Conditions

Metabolic Myopathies Exercise Test Muscular Diseases Musculoskeletal Diseases Musculoskeletal Pain Myalgia Nervous System Diseases Neurologic Manifestations Neuromuscular Diseases Pain Pathological Conditions, Signs and Symptoms Signs and Symptoms

Age range

5 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Centre Hospitalier Régional Universitaire

Brest, 29609, France

Location status: Recruiting

Location contact

Fabrice Rannou, MD, PhD

CONTACT

[email protected]

33(0)298347366

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Referred to the Physiology Department of Brest Hospital for a metabolic exercise test
  • Ability to provide informed consent

Exclusion criteria

  • Contraindication(s) to perform cardiopulmonary exercise testing (ATS/ACCP statement on cardiopulmonary exercise testing, Am J respi Care Med 167: 211-77, 2003)
  • Pregnancy or unknown pregnancy status.

Treatment and study plan

functional test

Device

subjects perform a metabolic exercise testing

matching genotype with phenotype

Genetic

Primary outcomes

  1. Whole-body dynamic exercise

    Time frame: Participants will be followed for an expected average of 1 year to determine whether a muscle biopsy is performed

    The relation between Cardiopulmonary exercise test variables and the results of muscle biopsy or genetic analysis will be evaluated.

  2. Grip-test

    Time frame: Participants will be followed for an expected average of 1 year to determine whether a muscle biopsy is performed

    The relation between Grip-test variables and the results of muscle biopsy or genetic analysis will be evaluated.

  3. Blood tests

    Time frame: Participants will be followed for an expected average of 1 year to determine whether a muscle biopsy is performed

    The results of blood analysis from samples performed before, during, and after exercise will be compared to the results of muscle biopsy or genetic analysis.

Study contacts

Contact information is provided by the study sponsor or research team.

Fabrice Rannou, MD, PhD

CONTACT

[email protected]

33(0)298347366

Fabrice Rannou, MD, PhD

CONTACT

[email protected]

33(0)298347366

Sponsors and collaborators

Lead sponsor

University Hospital, Brest

Other

Registry information

Official study title

Exercise Testing in Metabolic Myopathies

Acronym: RANNOU

Important dates

Study start
2008
Primary completion
2027
Study completion
2027
First posted
Feb 13, 2015
Registry last updated
Jan 22, 2020

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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