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Completed

NCT Number: NCT02830113

Metabolic Effects of Treatment of Chronic Periodontitis in Non-diabetic Subjects

This study was aimed at assessing the effects of non-surgical periodontal treatment (NSPT) of chronic periodontitis on insulin sensitivity, glucose tolerance, and serum C-reactive protein(CRP) level amongst non-diabetic subjects.

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Key information

Conditions

Periodontitis Diabetes Mellitus Endocrine System Diseases Glucose Intolerance Glucose Metabolism Disorders Hyperglycemia Hyperinsulinism Insulin Resistance Metabolic Diseases Mouth Diseases Nutritional and Metabolic Diseases Periodontal Diseases PreDiabetes Prediabetic State Stomatognathic Diseases

Age range

18 year–60 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

About this study

Subjects with chronic periodontitis will undergo non-surgical periodontal treatment (NSPT) consisting of a complete scaling, polishing, root planning, and the irrigation of periodontal pockets with a 10% povidone iodine solution. Periodontal parameters (plaque index, gingival bleeding index, pocket depth, and clinical attachment loss), insulin sensitivity using KITT, glucose tolerance using oral glucose tolerance test and serum CRP level by immunoturbidimetry will be measured before and 3 months after the NSPT.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Chronic periodontitis
  • Non diabetic individual

Exclusion criteria

  • Known diabetes
  • Periodontal treatment less than 6 months prior to inclusion
  • Having less than 20 natural teeth

Treatment and study plan

Non-surgical periodontal treatment

Procedure

One session of complete scaling, polishing, root planning, and the irrigation of periodontal pockets with a 10% povidone iodine solution

Primary outcomes

  1. Glucose tolerance

    Time frame: 3 months

    change in 2-hour post load blood glucose

  2. Insulin sensitivity

    Time frame: 3 months

    change in glucose disappearance rate during the short insulin tolerance test

Secondary outcomes

  1. Composite periodontal health

    Time frame: 3 months

    Change in plaque index, gingival bleeding index, pocket depth, and clinical attachment loss

  2. Inflammation

    Time frame: 3 months

    change in Serum CRP

Sponsors and collaborators

Lead sponsor

Yaounde Central Hospital

Other Gov

Collaborators

  • University of Yaounde 1

Registry information

Official study title

Effects of Non-surgical Treatment of Chronic Periodontitis on Insulin Resistance and Glucose Tolerance in Non-diabetic Subjects

Acronym: PARODIA2

Important dates

Study start
2014
Primary completion
2015
Study completion
2015
First posted
Jul 12, 2016
Registry last updated
Jul 12, 2016

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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