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OpenTrials
Completed

NCT Number: NCT00442390

Metabolic Effects of Acute Cortisol Withdrawal in Adrenal Failure

Effects of adrenal steroids is generelly drawn from studies of hypercortisolism. The effects of physiological cortisol substitution and withdrawal is studied and related to the clinical syndrome of adrenal insufficiency.

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Key information

Conditions

Addison Syndrome Adrenal Gland Diseases Adrenal Insufficiency Endocrine System Diseases Glucose Metabolism Disorders Hyperinsulinism Insulin Resistance Metabolic Diseases Nutritional and Metabolic Diseases

Age range

18 year–50 year

Sex eligibility

Female

Study type

Interventional

Phase

Not applicable

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Female adrenal failure
  • Age 18-50
  • Written informed content

Exclusion criteria

  • Diabetes mellitus
  • Cancer
  • Thromboembolic events
  • Pregnancy and lactation
  • Heart disease

Treatment and study plan

hydrocortisone substitution therapy versus withdrawal

Drug

Primary outcomes

  1. insulin sensitivity

  2. local protein turnover

  3. whole body protein turnover

  4. glucose metabolism

  5. serum metabolites

  6. serum hormone levels

Sponsors and collaborators

Lead sponsor

University of Aarhus

Other

Registry information

Official study title

Effects of Cortisol on Carbohydrate, Lipid, and Protein Metabolism; Studies of Acute Cortisol Withdrawal in Adrenocortical Failure.

Important dates

Study start
2002
Study completion
2003
First posted
Mar 1, 2007
Registry last updated
Mar 1, 2007

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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