Metabolic Disturbances in Polycystic Ovary Syndrome (PCOS)

The scope of the study was to investigate different metabolic aspects that may lead to or are a consequence of insulin resistance in premenopausal women with polycystic ovary syndrome (PCOS). We use gold standard methods for evaluation of insulin resistance. We take muscle and fat biopsies for investigation of gene expression of different cytokines associated with insulin resistance. We investigate the incretin hormones GIP and GLP-1. These two hormones play a central role in glycemic control, and diabetic subjects are known to have alterations in their incretin hormones. The incretin hormones have not previously been investigated in women with PCOS.

Completed

Looking for future studies?

Notify Me

Key information

Conditions

Polycystic Ovary Syndrome Adnexal Diseases Cysts Endocrine System Diseases Female Urogenital Diseases Female Urogenital Diseases and Pregnancy Complications Genital Diseases Genital Diseases, Female Gonadal Disorders Neoplasms Ovarian Cysts Ovarian Diseases Urogenital Diseases

Age range

18 year–38 year

Sex eligibility

Female

Study type

Observational

Primary location

Dpt. of Obstetrics and Gynaecology, Copenhagen University Hospital, Hvidovre

Hvidovre, 2650, Denmark

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Premenopausal women that meet the Rotterdam criteria for PCOS (BMI < 40)
Age and BMI matched control women that do not have any signs or symptoms of PCOS

Exclusion criteria

BMI > 40. mani fest diabetes or other known diseases

Treatment and study plan

Primary outcomes

insulin resistance

Time frame: 2004-2006

Secondary outcomes

gene expression of cytokines in fatty tissue

Time frame: 2004-2006

Sponsors and collaborators

Lead sponsor

Hvidovre University Hospital

Other

Collaborators

Aage Bangs Fond
Danish Hospital foundation for medical research. region Copenhagen, The Faroe Islands and Greenland.
Diabetesforeningen

Registry information

Official study title

Insulin Resistance in Polycystic Ovary Syndrome (PCOS)

Important dates

Study start: 2004
Primary completion: 2006
Study completion: 2006
First posted: Feb 4, 2008
Registry last updated: Feb 4, 2008

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed