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NCT Number: NCT07573930

Metabolic Control in Anesthesia and Surgery

The goal of this observational study is to investigate how a standard dose of the drug dexamethasone affects blood sugar levels during and after non-cardiac surgery in adult patients.

The main questions it aims to answer are:

* How does dexamethasone influence blood sugar levels in patients undergoing non-cardiac surgery? * Does continuous glucose monitoring (CGM) provide a more accurate estimate of blood sugar fluctuations compared to traditional time-specific finger-prick measurements?

Participants are scheduled to receive dexamethasone as part of standard anesthesia care and will undergo their planned surgery. As part of the study, a continuous glucose monitoring (CGM) device will be placed on their upper arm approximately 12 hours before surgery and will remain in place for up to 10 days after the operation. During this period, their blood sugar levels will be measured using both the CGM device and traditional finger-prick tests. CGM readings are blinded for both participants and clinicians. No additional treatments or changes to their standard care will be made as a result of their participation in the study.

The study will include 100 adult patients from the Department of Anesthesiology at Sjællands University Hospital, Roskilde.

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Key information

Conditions

Anesthesia Continuous Glucose Monitoring Hyperglycemia Steroid-induced Hyperglycemia Stress Surgical Procedure, Unspecified

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Zealand University Hospital

Roskilde, 4000, Denmark

Location status: Recruiting

Location contact

Anne M Brinck, MSc Medicine

CONTACT

[email protected]

+4552119003

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Adult patients (≥18 years) scheduled for elective non cardiac surgery
  • Expected surgery duration >1 hour
  • Administration of dexamethasone as part of standard anaesthetic regimen or planned by the responsible anaesthetist to enhance recovery or to limit risk of PONV.
  • Ability to provide written informed consent

Exclusion criteria

  • Not possible to obtain consent or permission
  • Known allergy or adverse reaction to dexamethasone
  • Type 1 diabetes (due to need for insulin titration)
  • Active infection, sepsis, or immunosuppression
  • Contraindications to continuous glucose monitoring (CGM)

Treatment and study plan

Primary outcomes

  1. Characterization of hyperglycemia I

    Time frame: Up to 10 days postoperatively

    Peak glucose level

  2. Characterization of hyperglycemia II

    Time frame: Up to 10 days postoperatively

    Duration of hyperglycemia

Secondary outcomes

  1. Correlation between pre- and postoperative glucose trajectories

    Time frame: Up to 10 days postoperatively

    How does baseline dysglyceamia (elevated FPG or HbA1C) correlates to intra- and postoperative hyperglycemia

  2. Subgroup analyses

    Time frame: Up to 10 days postoperatively

    Comparing diabetic vs. non-diabetic patients and patients with obesity (BMI ≥30) vs. non-obese (BMI <30), frail vs non-frail, fasting vs non fasting surgeries

Study contacts

Contact information is provided by the study sponsor or research team.

Anne M Brinck, MSc Medicine

CONTACT

[email protected]

+4552119003

Sponsors and collaborators

Lead sponsor

Zealand University Hospital

Other

Registry information

Official study title

Deteriorated Metabolic Control in the Perioperative Period in Surgical Patients: What is the Impact of Anesthetic Preparation and Patient Frailty?

Acronym: MACS

Important dates

Study start
2026
Primary completion
2028
Study completion
2028
First posted
May 7, 2026
Registry last updated
May 7, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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