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NCT Number: NCT06500156

Metabolic Cluster Analysis in Septic Shock Patients

Observational study including septic shock patients within 24 hours of ICU admission, monitored with a cardiac output estimation system, with ongoing resuscitation. Hemodynamic and metabolic parameters before and after a fluid challenge (FC) will be measured.

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Key information

Conditions

Septic Shock Infections Inflammation Pathologic Processes Pathological Conditions, Signs and Symptoms Sepsis Shock Shock, Septic Systemic Inflammatory Response Syndrome

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Hospital Universitari Parc Taulí

Sabadell, Barcelona, 08208, Spain

Location status: Recruiting

Location contact

Edgar Cortés, MD

SUB_INVESTIGATOR

Ferran Oller, MD

CONTACT

[email protected]

Ferran Oller, MD

PRINCIPAL_INVESTIGATOR

Guillem Gruartmoner, MD

SUB_INVESTIGATOR

Jaume Mesquida, MD

CONTACT

[email protected]

+34937231010

Jaume Mesquida, MD

PRINCIPAL_INVESTIGATOR

Sara Nogales, MD

SUB_INVESTIGATOR

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Septic shock patients within the first 24 hours of ICU admission, and selected by the attending physician for performing a fluid challenge (FC) due to suspected tissue hypoperfusion (elevated lactate and/or ScvO2 < 70%).

Exclusion criteria

  • Age under 18 years old
  • Uncontrolled hemodynamic instability, defined as the need for significant changes in vasopressor support (> 10% from baseline dose) within the 15-minute period prior to, and/or during the administration of fluids.
  • Patients receiving continuous renal replacement therapies, since the CO values obtained from the thermodilution techniques might be potentially affected.

Treatment and study plan

Fluid challenge

Other

Rapid infusion (< 15 minutes) of a fluid bolus of crystalloids (200 to 500cc)

Primary outcomes

  1. VO2-response

    Time frame: 30 minutes

    Percentage increase in VO2 as results of the fluid challenge

Secondary outcomes

  1. Organ failure

    Time frame: 4 days

    Assessment of the SOFA score at day 1, 2 and 4

  2. Mortality

    Time frame: 28 days

    Mortality within the first 28 days

Study contacts

Contact information is provided by the study sponsor or research team.

Ferran Oller, MD

CONTACT

[email protected]

Jaume Mesquida, MD

CONTACT

[email protected]

+34937231010

Sponsors and collaborators

Lead sponsor

Corporacion Parc Tauli

Other

Registry information

Official study title

Metabolic Cluster Analysis in Septic Shock Patients Undergoing Hemodynamic Resuscitation. A Multicenter Observational Study

Acronym: ACMEcat

Important dates

Study start
2024
Primary completion
2026
Study completion
2026
First posted
Jul 15, 2024
Registry last updated
Dec 5, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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