Metabolic Characteristics and Prognostic Model of Acute Coronary Syndrome Complicated With Obstructive Sleep Apnea

Obstructive sleep apnea (OSA) significantly increases the risk of cardiovascular events in patients with acute coronary syndrome (ACS), yet the underlying metabolic mechanisms remain unclear. This study aims to analyze the metabolic characteristics of ACS patients with OSA using metabolomics based on a prospective cohort. The study intends to construct an artificial intelligence-based risk stratification model to improve prognosis prediction and facilitate precision medicine for this population.

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Key information

Conditions

Sleep Disordered Breathing (SDB) Apnea Dyssomnias Nervous System Diseases Respiration Disorders Respiratory Tract Diseases Sleep Apnea Syndromes Sleep Disorders, Intrinsic Sleep Wake Disorders

Age range

18 year–85 year

Sex eligibility

All sexes

Study type

Observational

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Age 18-85 years.
Diagnosed with ACS, including ST-segment elevation myocardial infarction, non-ST-segment elevation myocardial infarction, and unstable angina.
Willing to participate and sign the informed consent form.

Exclusion criteria

Cardiogenic shock or cardiac arrest.
Central sleep apnea or other types of sleep disordered breathing.
Previous or current treatment with continuous positive airway pressure.
Inability to complete polysomnography or invalid data.
Malignancy or life expectancy < 1 year.

Treatment and study plan

Biological sample collection

Other

Collection of blood, urine, and stool samples for metabolomics analysis.

Primary outcomes

Incidence of Major Adverse Cardiovascular and Cerebrovascular Events (MACCE)

Time frame: 12 Months

Study contacts

Contact information is provided by the study sponsor or research team.

Wei Gong

CONTACT

[email protected]

+86 13717676086

Sponsors and collaborators

Lead sponsor

Beijing Hospital

Other Gov

Registry information

Official study title

Metabolic Characteristics Analysis and Precise Prognostic Model Establishment for Patients With Acute Coronary Syndrome Complicated With Obstructive Sleep Apnea

Acronym: OSA-ACS-Met

Important dates

Study start: 2026
Primary completion: 2027
Study completion: 2027
First posted: Feb 9, 2026
Registry last updated: Feb 9, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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