Metabolic and Clinical Effects of Hyperchloremia During HoLEP Surgery.

This study aims to evaluate the changes between preoperative and postoperative serum chloride levels in patients undergoing HoLEP surgery and to investigate the metabolic and clinical effects of this change. The study is observational, and no additional interventions will be performed.

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Key information

Conditions

HoLEP (Holmium Laser Enucleation of Prostate) Hyperchloremia Perioperative Management

Age range

18 year and older

Sex eligibility

Male

Study type

Observational

About this study

Although isotonic irrigation fluids used in HoLEP surgery reduce the risk of hyponatremia associated with TUR syndrome, high-volume fluid absorption may lead to hyperchloremia and subsequent metabolic acidosis. This prospective, observational, single-center study, conducted at Ankara Bilkent City Hospital, aims to identify early markers of this condition to optimize perioperative management.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Patients scheduled for elective HoLEP surgery.
Patients providing written informed consent

Exclusion criteria

Preoperative metabolic acidosis.
Advanced renal failure.
Emergency surgery.
Missing data.

Treatment and study plan

HoLEP surgery

Procedure

All parameters are part of routine clinical practice; no additional examinations are required

Primary outcomes

Change in serum chloride level

Time frame: Perioperative

Secondary outcomes

irrigation volume

Time frame: Perioperative
Arter blood gas

Time frame: Perioperative

Sponsors and collaborators

Lead sponsor

Ankara City Hospital Bilkent

Other

Registry information

Official study title

Evaluation of the Metabolic and Clinical Effects of Intraoperative Hyperchloremia in Holmium Laser Enucleation of Prostate (HoLEP) Surgery.

Important dates

Study start: 2026
Primary completion: 2026
Study completion: 2026
First posted: Jun 18, 2026
Registry last updated: Jun 18, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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