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OpenTrials
Completed

NCT Number: NCT04006483

Meta-analysis of Stannous Fluoride and the Effects on Dental Plaque

The aim of this 18 study analysis was to compare the effect of bioavailable stannous fluoride (SnF2) dentifrices when used up to 3 months on dental plaque relative to a positive or negative control dentifrice.

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Key information

Conditions

Dental Plaque Dental Deposits Stomatognathic Diseases Tooth Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Multiple P&G Investigation Clinical Sites

Cincinnati, Ohio, 45040, United States

Who can participate

Only the study team can determine whether someone qualifies for participation.

Subjects were excluded from this study for the following reasons;

  • pregnancy,
  • rampant caries,
  • severe periodontitis,
  • at discretionary of the Principal Investigator.

Treatment and study plan

Stannous Fluoride Dentifrice

Drug

Stannous fluoride (0.454%) dentifrice

Positive control dentifrice

Drug

Positive control dentifrice containing (0.3%) triclosan.

Negative Control Dentifrice

Drug

Negative control dentifrice containing either sodium fluoride (0.243%) or sodium monofluorophosphate (0.76%)

Primary outcomes

  1. Dental Plaque Scores

    Time frame: Up to 12 weeks

    Change from baseline as measured by mean plaque score reduction from baseline (via Quigley-Hein, Turesky Modification Index or Rustogi Modification of the Navy Plaque index).

Sponsors and collaborators

Lead sponsor

Procter and Gamble

Industry

Registry information

Official study title

A Review of Meta-Analyses on Bioavailable Stannous Fluoride Dentifrices: Effects on Dental Plaque

Important dates

Study start
2018
Primary completion
2018
Study completion
2018
First posted
Jul 5, 2019
Registry last updated
Nov 18, 2023

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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