Menopausal Treatment Using Relaxation Exercises (MaTURE)

Inclusion criteria

• Women aged 40 through 59 years at the time of screening.
• Perinenopausal or postmenopausal.
• Adequate adherence to study procedures during a 1-week run-in.
• At least 4 hot flashes per 24 hours recorded by a hot flash monitor and diary.
• Capable of understanding study procedures and giving informed consent.
• Willing to refrain from using other treatments for hot flashes during the study period.

Exclusion criteria

• Pregnant or breastfeeding in the past year.
• Current or recent use of medications known to affect hot flashes.
• Resting blood pressure less than 100/60.
• Spontaneous resting breathing rate less than 10 breaths/minute.
• Chronic medical therapy for pulmonary disease.
• Known sensitivity to adhesives.
• Cardiac pacemaker or implanted defibrillator.
• No access to a telephone.
• Plans to move out of the area or travel by airplane in ways that would interfere with the study.
• Inability to sign an informed consent, participate in interviews, or understand and complete questionnaires in English.
• Report conditions that, in the judgment of the investigators, render potential participants unlikely to follow the protocol.
• Participation in another research study involving investigational drugs or devices.