Menopausal Impact on Skin Aging Among Egyptian Women

The goal of this study is to understand how menopause affects skin aging in Egyptian women between the ages of 40 and 60.

The main question the study wants to answer is:

Does menopause cause any changes in how the skin ages?

To find out, the participants will be divided into two groups based on their menstrual history:

* Women who have not yet gone through menopause (premenopausal) * Women who have already gone through menopause (postmenopausal) A researcher will examine the skin of women in both groups to look for signs of aging. Then, the results will be compared to see if there are any differences between the two groups.

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Key information

Conditions

Skin Aging

Age range

40 year–60 year

Sex eligibility

Female

Study type

Observational

Who can participate

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Females aged 40 to 60 years
Egyptian nationality or residency
Ability to provide informed consent
Classified as either:

Premenopausal (still menstruating regularly)
Postmenopausal (no menstruation for ≥12 months)

Exclusion criteria

Menopausal transition (Perimenopausal women
Menopause induced by hysterectomy
History of hormone therapy in the past 6 months
Active dermatological conditions affecting the face (e.g. eczema, psoriasis)
Use of anti-aging skin treatments (e.g. laser, fillers, retinoids)
Severe chronic illnesses that may affect skin condition

Treatment and study plan

Dermoscopy

Device

dermoscopic assessment of skin aging signs

Primary outcomes

Clinical skin aging severity using Glogau Photoaging Scale

Time frame: Assessed once at baseline during participant's visit

The Glogau Photoaging Scale will be used for evaluation. Facial assessment will be conducted both at rest and during facial animation to observe dynamic changes. Participant will be categorized into 4 types or grades where type 1 is mild skin aging and type 4 is severe skin aging
Dermoscopic skin aging score using the dermoscopic photoaging assessment scale

Time frame: Assessed once at baseline during participant 's visit

this scale is used to assess facial skin aging. The face will be divided into four regions: the forehead, right cheek, left cheek, and chin. Each region will be examined for the presence of the following features: yellowish discoloration, yellow papules, white linear areas indicating skin atrophy, lentigines, hypo- or hyperpigmented macules, telangiectasia, actinic keratoses, senile comedones, deep wrinkles, superficial wrinkles, and criss-cross wrinkles. Scoring follows a binary (yes/no) approach, where the presence of a given feature in any of the four regions scores one point, yielding a total possible score ranging from 0 to 44. a higher score means worse outcome.

Secondary outcomes

Prevalence of specific clinical and dermoscopic aging features

Time frame: Recorded during clinical and dermoscopic assessment at baseline
Correlation between menopausal status and severity of skin aging

Time frame: Assessed once at baseline during participant's visit based on menopausal history and skin aging scores
Correlation between menopausal duration and skin aging

Time frame: Menopausal duration collected via history at baseline; skin aging assessed at baseline

Sponsors and collaborators

Lead sponsor

Sohag University

Other

Registry information

Official study title

Menopausal Impact on Skin Aging Among Egyptian Women: a Comparative Cross-sectional Study

Important dates

Study start: 2025
Primary completion: 2026
Study completion: 2027
First posted: Aug 13, 2025
Registry last updated: Aug 13, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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