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NCT Number: NCT03595761

Meningitis With Cerebral Vasculitis in Children

Purulent meningitis are life-threatening diseases in childhood. Cerebral vasculitis have been described in bacterial meningitis, but poor is known about their physiology and their impact on outcome.

The investigators decide to realize a retrospective mono-centric study carried out at Montpellier university hospital which looks back at a 7-year study(2009-2016).

The Investigators selected purulent meningitis cases based on the bacteriological data provided by the HDB (hospital data base). The Investigators divides in two groups : Group A if patients present a cerebral vasculitis ( radiologic diagnostic by RMI or tomodensitometry), in all, cases the diagnosis of vasculitis was confirmed by a radiologist specialised in neuropaediatrics by a second reading;Group B purulent meningitis with a cerebral vasculitis imaging.

Tuberculous meningitis, meningitis in CSF shunt, and in patients having chemotherapy were excluded.

The investigators report clinical and biological finding, inflammatory marker at the onset. The Investigators register also the clinical evolution and sequelae

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Key information

Conditions

Bacterial Meningitis Autoimmune Diseases Autoimmune Diseases of the Nervous System Bacterial Infections Bacterial Infections and Mycoses Brain Diseases Cardiovascular Diseases Central Nervous System Bacterial Infections Central Nervous System Diseases Central Nervous System Infections Cerebrovascular Disorders Immune System Diseases Infections Meningitis Meningitis, Bacterial Nervous System Diseases Neuroinflammatory Diseases Vascular Diseases Vasculitis Vasculitis, Central Nervous System

Age range

1 day–18 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Uhmontpellier

Montpellier, 34290, France

About this study

Meningitis steel are a cause of death in childhood. Cerebral complication are often responsable of poor prognosis. One of these complication vasculitis is steel not weel understood. There are only few study about it on children.

It is a retrospective study about 17 cases of chil which bacterial meningitis coupled wiethe cerebral vasculitis, the Investigators will describe epidemiology, bacteriology, evolution and corticosteroid treatment in this patients.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • bacterial meningitis with LCR confirmation

Exclusion criteria

  • tuberculous meningitis, immunosuppressor treatment, material like DVP

Treatment and study plan

Primary outcomes

  1. Found a difference demographic data

    Time frame: 1 day

    Found a difference demographic data between population A and B (age)

  2. Found a difference demographic data

    Time frame: 1 day

    Found a difference demographic data between population A and B (gender)

  3. Found a difference Clinical manifestation

    Time frame: 1 day

    Found a difference Clinical manifestation between population A and B

  4. Found a difference Inflammatory parkers

    Time frame: 1 day

    Found a difference Inflammatory parkers between population A and B

  5. Found a difference Infectious agent

    Time frame: 1 day

    Found a difference Infectious agent between population A and B

Secondary outcomes

  1. Found a difference in the evolution of the diseases between group A and B

    Time frame: 1 day

    The data analysed will be : presence of seizure within the next 6 month before the last survey, necessity of antiepileptic treatment, development delay, presence of neurologic deficiency(palsy), persistence of abnormality on neuroimaging.

  2. In the A group, studying the relationship between prescription of steroids pulse and final outcome and presence of sequelae.

    Time frame: 1 day

    Sequelae will be defined by the presence of one of this element : : presence of seizure within the next 6 month before the last survey, necessity of antiepileptic treatment, development delay, presence of neurologic deficiency(palsy), persistence of abnormality on neuroimaging.

Sponsors and collaborators

Lead sponsor

University Hospital, Montpellier

Other

Registry information

Official study title

Retrospective Study About 17 Cases of Child With Bacterial Meningitis Coupled With Cerebral Vasculitis

Important dates

Study start
2017
Primary completion
2017
Study completion
2017
First posted
Jul 23, 2018
Registry last updated
Jul 26, 2018

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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