Memory Neuroimaging in Children, Adolescents and Young Adults Following Pediatric Cancer

Inclusion criteria

FOR ALL PARTICIPANTS

• Affiliation to or beneficiary of a social security scheme
• French mother tongue
• Sufficient visual, auditory (hearing aids permitted), speaking and writing skills for proper performance of neuropsychological tests
• Written informed consent of the adult participant, or of the representatives of parental authority, if applicable

FOR IRRADIATED PATIENTS

• Patient treated before 18 years old
• Patient considered cured after irradiation of a brain tumour (complete clinical and iconographic response at 5 years after the end of radiotherapy).
• Patient who has received localized brain irradiation or craniospinal irradiation for a brain tumour whose treatment includes first-line radiotherapy (ependymomas, medulloblastomas, malignant germinal tumours)
• Patient who received 54 or 59.4 Gy in a localized part of the posterior fossa or supra-tentorial brain; or patients who received 54 Gy over all or part of the posterior fossa and prophylactic irradiation of the entire brain

FOR PATIENTS TREATED BY SURGERY AND/OR CHEMOTHERAPY

• Patients resected from a posterior fossa tumour without radiotherapy (i.e., brain tumours whose treatment does not include first-line radiotherapy: low-grade gliomas including pilocytic astrocytomas)
• Patient treated before 18 years old
• Patient considered cured at 5 years after the end of treatment

Exclusion criteria

FOR ALL PARTICIPANTS

• Individual under legal protection of adults (judicial safeguard, guardianship, curatorship, institutionalized, or under a mandate for future protection)
• Severe ataxia
• Individual who participated in another research study that included treatment within the previous 3 years
• Individual with a contraindication to MRI (i.e. in particular, cardiac pacemaker or defibrillator carriers, implanted equipment activated by an electrical, magnetic or mechanical system, carriers of haemostatic clips on intracerebral aneurysms, carriers of orthopaedic implants, claustrophobic)

FOR HEALTHY VOLUNTEERS

• Known neurological or psychiatric history
• History of learning disability or neurodevelopmental disorder follow-up
• Patients undergoing psychotropic treatment (methylphenidate, antidepressants, etc.).