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OpenTrials
Completed

NCT Number: NCT03897855

Memory Inhibition and Delayed Onset Post-traumatic Stress Disorder in Older Subjects

In the elderly, we can see a post-traumatic syndrome associated with an event that occurred before old age that had not previously manifested or not fully manifested.

This little-known pathology and notable psychiatric co-morbidities (depression, anxiety) can take in elderly subjects different masks that interfere with diagnosis and treatment.

The data in the literature suggest that this Post-Traumatic Stress Disorder with Delayed Expression (TSPT-R) may be related to a deficiency of the executive functions of inhibition, and more particularly a deficit of mental memory inhibition and therefore the removal of unwanted memories.

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Key information

Conditions

Post-Traumatic Stress Disorder in Old Age

Age range

65 year–85 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Centre Hospitalier de Niort

Niort, 79021, France

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

-

Regarding the constitution of the group patient (TSPT-R):

  • Subjects 65 years of age or older
  • Clinical diagnosis of delayed-onset PTSD according to DSM-5 criteria after 65 years
  • The traumatic event must have taken place at the latest before 65 years
  • Affiliated person or beneficiary of a social security scheme.
  • Written consent before any examination required by research)

Regarding the constitution of the control group:

  • Subjects 65 years of age or older
  • No diagnosis of PTSD (delayed or not) or history of PTSD (delayed or not)
  • Affiliated person or beneficiary of a social security scheme.
  • Written consent before any examination required by the research).

Exclusion criteria

  • For both groups:
  • Acute or chronic cognitive impairment known
  • GRECO MMSE pathological score less than or equal to the pathological threshold weighted according to level of education and age, namely:
  • 22 if no diploma
  • 23 if certificate of study
  • 25 if patent
  • 26 if bin or more
  • Remove one point at each threshold if age> 80 years
  • Sensory or motor disorder preventing the passing of different tests
  • Psychotic disorder
  • Mood disorder in decompensation (for depression, HAD-D score equal to or greater than 11)
  • Disorder of the use of a moderate or severe substance (except tobacco).
  • Patients under guardianship or curatorship.

Treatment and study plan

Post Traumatic Stress Disorder

Other

The test "Think / No-Think"

Primary outcomes

  1. Inhibition score measured by the Think / No-Think Test

    Time frame: 1 month

    the average of the inhibition score measured by the "Think / No-Think" test as defined by Anderson and Green (2001) and then reviewed by Anderson et al. in 2011

Sponsors and collaborators

Lead sponsor

Centre Hospitalier de Niort

Other

Registry information

Acronym: I-TSPT-R

Important dates

Study start
2019
Primary completion
2019
Study completion
2021
First posted
Apr 1, 2019
Registry last updated
Jul 30, 2021

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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