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Completed

NCT Number: NCT02953964

Memory Encoding Strategies for People With Mild Cognitive Impairments

The purposes of the study are:

* To evaluate the effectiveness of a perceptual-based training program in enhancing cognitive and everyday functioning of older adults with mild cognitive impairment and mild dementia * To evaluate the effectiveness of a semantic-based training program in enhancing cognitive and everyday functioning of older adults with mild cognitive impairment and mild dementia

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Key information

Conditions

Mild Cognitive Impairment Cognition Disorders Cognitive Dysfunction Mental Disorders Mild Dementia Neurocognitive Disorders

Age range

60 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Western Sydney University, Penrith, New South Wales, Australia

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About this study

People with dementia experience a cognitive decline that affects their functional performance. It has been identified that encoding is less effective in people with dementia. Rehabilitating at the encoding stage is, therefore, essential. A recent systematic review found that effective interventions needed to include training in individually selected memory encoding strategies. These strategies are classified as either perceptual (visual) or semantic (association) memory encoding strategies.

Based on the above literature, the chief investigator (Associate Professor Karen Liu) ran a pilot study on an integrated home and community centre cognitive training programme for 20 elderly people with memory problem using a pre-test and post-test comparison design.

Extending on the positive results, the aim of this project was to investigate the effectiveness of perceptual and semantic encoding strategies (and compare with a control intervention). It also aims to promote the understanding of memory loss and dementia and the need for early intervention for family members of the participants.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Selection Criteria:

  • are aged 60 or above;
  • have no previous psychiatric or memory disorder history or other neurological illness;
  • have Mini-mental State Examination score (MMSE) greater than or equal to 21;
  • have Clinical Dementia Rating score (CDR) of 0.5 or 1 indicating very mild and mild dementia;
  • do not show sign of depression with score below 9 out of 30 in the Geriatric Depression Scale;
  • are able to communicate effectively;
  • have family member who can participate in the study; and
  • voluntarily consent to participate in the study.

Treatment and study plan

Behavioral: perceptual-based memory encoding training

Other

Participants are trained in the use of perceptual-based memory encoding strategies, inclusive of visual imagery and the method of loci. Visual imagery involves the creation and encoding of mental images, while the method of loci refers to linking these images with specific places to facilitate memory (Simon et al., 2012). Participants are taught to visualise performing each step of a task in a familiar environment, such as in their home (Liu et al., 2009). After participants can correctly visualise the entire task, they then progress to actually performing the task. During the intervention sessions, 2-3 tasks are covered each session, and these tasks become progressively difficult as the weeks progress. The intervention lasts for 10 weeks with one session every week. Each session runs for 90 minutes. A follow-up home training program is run once a week for 30 minutes with the participant and their care-giver.

Behavioral: semantic-based memory encoding training

Other

Participants are asked to encode the steps of a task by forming an association of the steps and sequence. Participants are trained in the use of the chunking association method and honeycomb concept and perform different tasks each week, implementing this encoding strategy (Lim et al., 2012). The chunking association method breaks down information into smaller parts and helps with the encoding and retrieval of information. The honeycomb concept allows the steps to form a story in relation to place, time, characters, problem and solution and the story is verbalised. Participants then complete the task. During the intervention sessions, 2-3 tasks are covered each session, and these tasks become progressively difficult as the weeks progress. The intervention lasts for 10 weeks with one session every week. Each session runs for 90 minutes. A follow-up home training program is run once a week for 30 minutes with the participant and their care-giver.

Behavioral: Cognitive stimulation group (control group)

Other

Participants receiving cognitive stimulation intervention. It consists of eight sessions that train participants' visual attention and memory, auditory attention and memory and their application in daily activities. Two sessions are also given which allow for participants to apply the training practically in their daily lives. The intervention lasts for 10 weeks with one session every week. Each session runs for 90 minutes. A follow-up home training program is run once a week for 30 minutes with the participant and their care-giver.

Other names: Cognitive stimulation group

Primary outcomes

  1. Change in Disability Assessment for Dementia

    Time frame: Within two days before the intervention and within two days after the 10-week intervention

    Change in Disability Assessment for Dementia to assess assistance required in basic daily tasks such as dressing, bathing

  2. Change in Instrumental Activities of Daily Living Scale

    Time frame: Within two days before the intervention and within two days after the 10-week intervention

    Change in Instrumental Activities of Daily Living Scale to assess assistance required in instrumental daily tasks such as laundry, meal preparation

Secondary outcomes

  1. Change in Cognistat

    Time frame: Within two days before the intervention and within two days after the 10-week intervention

    Change in Cognistat to assess general cognitive function

  2. Change in Digit Span Test

    Time frame: Within two days before the intervention and within two days after the 10-week intervention

    Change in Digit Span Test to assess attention and working memory

  3. Change in Consortium to Establish a Registry for Alzheimer's Disease

    Time frame: Within two days before the intervention and within two days after the 10-week intervention

    Change in Consortium to Establish a Registry for Alzheimer's Disease to assess cognitive function in verbal fluency, memory

Sponsors and collaborators

Lead sponsor

University of Western Sydney

Other

Registry information

Official study title

Perceptual and Semantic Memory Encoding Strategies for People With Mild Cognitive Impairment

Important dates

Study start
2010
Primary completion
2015
Study completion
2015
First posted
Nov 3, 2016
Registry last updated
Nov 3, 2016

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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