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Completed

NCT Number: NCT00736203

Memory and Picture Viewing Study

The purpose of this study is to obtain a database of brain function from a sample of non-smokers while they do tasks in an MRI (magnetic resonance imaging) machine. Our hypothesis is that among nonsmokers, reactivity to smoking cues will be highly similar to control cues but may vary as a function of attitudes toward smoking and/or family history of smoking. We also hypothesize that brain activity during the n-back task will be more similar to data collected during this task when smokers are not abstinent.

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Key information

Conditions

Healthy Brain Reactivity of Non-smokers Undergoing fMRI Scanning

Age range

18 year–55 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Duke University Medical Center

Durham, North Carolina, 27705, United States

About this study

Thirty six non-smokers will undergo functional magnetic resonance imaging (fMRI) scanning. During scanning participants will complete the n-back task-a measure of working memory-and the cue-reactivity task-a measure of responses to smoking cues. Before scanning, participants will complete a training session where they will be familiarized with the tasks.

All participants will have to pass a screening visit in order to be included in the study.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • generally healthy
  • right-handed non-smokers
  • between the ages of 18-55
  • an expired CO concentration of 5 ppm or less; or a negative urine cotinine test of 100 ng/mL or less (to confirm a non-smoker)
  • having smoked < 50 cigarettes in their lifetime

Exclusion criteria

  • inability to attend all sessions
  • significant health problems (hypertension, emphysema, seizure disorder, history of significant heart problems)
  • use of psychoactive medications
  • use of any tobacco or nicotine containing products
  • current alcohol or drug abuse
  • use of illegal drugs as measure by a urine drug screen
  • presence of conditions that would make MRI unsafe (pacemaker, metallic implants

Treatment and study plan

Primary outcomes

  1. brain reactivity

    Time frame: 3 weeks

Sponsors and collaborators

Lead sponsor

Duke University

Other

Collaborators

  • National Institutes of Health (NIH)

Registry information

Acronym: MPVS

Important dates

Study start
2008
Primary completion
2011
Study completion
2011
First posted
Aug 15, 2008
Registry last updated
Feb 7, 2013

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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