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OpenTrials
Completed

NCT Number: NCT00757978

Memantine as Adjunctive Therapy for Schizophrenia Negative Symptoms

Memantine as an add-on therapy to clozapine may improve schizophrenia negative symptoms and cognitive functioning.

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Key information

Conditions

Schizophrenia Mental Disorders Schizophrenia Spectrum and Other Psychotic Disorders

Age range

18 year–60 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Phase 4

Primary location

Hospital de Clinicas de Porto Alegre

Porto Alegre, Rio Grande do Sul, 90035-903, Brazil

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Under clozapine with negative symptoms

Exclusion criteria

  • Pregnancy
  • Lactation

Treatment and study plan

Memantine

Drug

memantine 10mg twice a day

Other names: Ebixa

Placebo

Drug

1 capsule of placebo twice a day

Other names: Starch

Primary outcomes

  1. Score in Brief Psychiatric Raring Scale

    Time frame: baseline, 4 weeks, 8 weeks, 12 weeks

Sponsors and collaborators

Lead sponsor

Hospital de Clinicas de Porto Alegre

Other

Registry information

Official study title

Phase 4 Memantine as Adjunctive Therapy for Schizophrenia Negative Symptoms in Patients Using Clozapine. A Randomized, Double-Blind, Placebo Controled Study

Important dates

Study start
2006
Primary completion
2008
Study completion
2008
First posted
Sep 23, 2008
Registry last updated
Dec 18, 2008

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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