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Enrolling by Invitation

NCT Number: NCT07316582

Melatonin Loaded in Injectable Platelet-Rich Fibrin in the Management Periodontitis

melatonin loaded in injectible platelet rich fibrin in treatment of periodontitis

Enrolling by Invitation

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Key information

Conditions

Periodontitis Stage II Mouth Diseases Periodontal Diseases Periodontitis Stomatognathic Diseases

Age range

20 year–60 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Phase 4

Primary location

Faculty of Dental Medicine for girls Al-Azhar University

New Cairo, Egypt

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Diagnosed with stage II periodontitis based on AAP/EFP 2018 classification
  • Minimum of two non-adjacent periodontal pockets <5 mm in different quadrants
  • Systemically healthy individuals willing to participate and comply with follow-up visits
  • Radiographic bone loss (ranged from is 10-20% mostly horizontal

Exclusion criteria

History of systemic diseases affecting periodontium (e.g., diabetes, osteoporosis)

  • Use of antibiotics, anti-inflammatories, or antioxidant supplements in the past 3 months
  • Smoking or tobacco use
  • Pregnancy or lactation
  • Allergy to melatonin or related compounds

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Treatment and study plan

Melatonin-Loaded Injectable Platelet-Rich Fibrin

Drug

patients will be included in this group receiving SRP with Melatonin loaded in (I-PRF) using insulin syringe for injection

injectible platelet rich fibrin (i-PRF )

Biological

patients will be included in this group receiving (SRP) with local application of i-PRF

Primary outcomes

  1. Clinical attachment level (CAL)

    Time frame: 6 months

Sponsors and collaborators

Lead sponsor

Al-Azhar University

Other

Registry information

Official study title

Clinical and Biochemical Evaluation of Melatonin Loaded in Injectable Platelet-Rich Fibrin in the Management of Stage II Grade A Periodontitis: A Randomized Controlled Clinical Trial

Important dates

Study start
2025
Primary completion
2026
Study completion
2026
First posted
Jan 5, 2026
Registry last updated
Jan 5, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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