Melatonin Decreases Eye Pressure in Normotensive Patients

Agomelatine is a melatonin drug used to treat depressive disorder. Agomelatine may also some effects on ocular pressures. In this study, we aimed to demonstrate that melatonin decreases intraocular pressures when given depressive patients.

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Key information

Conditions

Depressive Disorder Behavior Behavioral Symptoms Depression Mental Disorders Mood Disorders

Age range

18 year–66 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Kahramanmaras Sutcuimam University Ophthalmology Department

Kahramanmaraş, 46050, Turkey (Türkiye)

About this study

Melatonin has been shown to be effective to decrease intraocular pressure in experimental animal researches. Agomelatine is a melatonin derivative drug approved for the treatment of depression, which is also available in our country. Depending on animal experiments, it can be assumed that agomelatine can decrease intraocular pressure. Demonstrating that agomelatine is effective to reduce eye pressure may give a concurrent treatment of depressive patients with glaucoma. With this it may be possible to treat both diseases at the same time with single drug. In this study, the researchers intended to investigate the changes in ocular tension in normotensive depressive patients treated with agomelatine.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Depressive patients suitable for Agomelatine therapy for the treatment of their primary disease.

Exclusion criteria

Any past history of ocular surgery, ocular trauma or existing ocular diseases

Treatment and study plan

Agomelatine 25 MG Oral Tablet

Drug

We will treat our patients with Agomelatine tablet of 25 mg.

Primary outcomes

Intraocular pressure

Time frame: One month

mmHg

Sponsors and collaborators

Lead sponsor

Kahramanmaras Sutcu Imam University

Other

Registry information

Official study title

Melatonin Decreases Eye Pressure in Depressive Patients With Normal Intraocular Pressure

Important dates

Study start: 2017
Primary completion: 2017
Study completion: 2018
First posted: Jun 20, 2017
Registry last updated: Aug 13, 2018

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed