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NCT Number: NCT07518381

Medication Understanding in MS

The goal of this observational study is to learn how people with multiple sclerosis (MS) understand, organise, and use their medicines at home. The study aims to explore how people take their prescribed and non-prescribed medicines, what challenges they experience, and whether any safety issues arise in day-to-day medication use.

Participants will take part in one home visit with trained student researchers. During the visit, researchers will review all medicines and supplements the participant uses, ask about routines and any difficulties, check medication packaging with permission, and ask a brief question about memory. No treatment changes will be made. Information will be reviewed by a senior clinician, and any safety concerns will be shared with the participant's usual healthcare team.

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Key information

Conditions

Multiple Sclerosis Autoimmune Diseases Autoimmune Diseases of the Nervous System Demyelinating Autoimmune Diseases, CNS Demyelinating Diseases Immune System Diseases Nervous System Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Adults aged 18 years and over with a confirmed diagnosis of multiple sclerosis
  • Living in the community (not in residential care)
  • Taking at least one prescribed medication
  • Able to provide informed consent or, for those without capacity to provide informed consent, with a consultee available to provide consultee declaration and provide information during home-based medication review
  • Willing and able to participate in a home-based medication review

Exclusion criteria

  • Severe cognitive or communication impairment without a consultee to provide consultee declaration and medication-related information
  • Participants for whom a home visit is deemed unsafe
  • Non-English speakers

Treatment and study plan

Primary outcomes

  1. Medication Burden (Descriptive)

    Time frame: Baseline

    Total number of prescribed and non-prescribed medications and supplements used by each participant, recorded during the home-based medication review. This includes dose, frequency, route, and source of each item. The outcome will be summarised descriptively (counts, means, ranges).

Secondary outcomes

  1. Medication Adherence (MARS-5 Score)

    Time frame: Baseline

    Self-reported adherence measured using the 5-item Medication Adherence Report Scale (MARS-5). Scores range from 5 to 25, with higher scores indicating better adherence. Results will be summarised descriptively.

  2. Medication-Related Challenges

    Time frame: Baseline

    Proportion of participants reporting difficulties with medication supply, administration, formulation, or perceived effectiveness, based on structured trigger questions. Reported descriptively.

  3. Subjective Cognitive Decline (Single-Item Question)

    Time frame: Baseline

    ("Yes"/"No") to the validated single-item subjective cognitive decline question ("Do you feel you have more problems with your memory than most?"). Used to contextualise medication-taking behaviours. Summarised descriptively.

  4. Medication Organisation and Use of Aids

    Time frame: Baseline

    Use of medication aids such as dosette boxes, blister packs, phone reminders, or charts. Recorded as present/absent and described using frequencies.

  5. Medication Storage and Safety Issues

    Time frame: Baseline

    Number and type of potential safety issues identified during the home visit, including expired medicines, duplicate supplies, unmonitored supplements, or storage concerns. Summarised descriptively.

Study contacts

Contact information is provided by the study sponsor or research team.

Laura Edwards, FRCP PhD

CONTACT

[email protected]

01332258238

Sponsors and collaborators

Lead sponsor

University of Nottingham

Other

Collaborators

  • Nottingham University Hospitals NHS Trust
  • University Hospitals of Derby and Burton NHS Foundation Trust

Registry information

Official study title

Home-based Assessment of Medication Understanding and Use in People With Multiple Sclerosis

Acronym: MUMS

Important dates

Study start
2026
Primary completion
2026
Study completion
2026
First posted
Apr 8, 2026
Registry last updated
Apr 8, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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