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Completed

NCT Number: NCT04040855

Medication Reviews in Elderly in Primary Care

The study is a follow-up of a randomized controlled study performed in 2011-2012 with medication reviews in elderly patients in Sweden. Additional data about mortality and hospital admissions have been collected.

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Key information

Conditions

Drug Utilization Review

Age range

75 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

About this study

Background Drug-related problems among the elderly population are common and increasing. Multi-professional medication reviews (MR) have arisen as a method to optimize drug therapy for frail elderly patients. Research has not yet been able to show conclusive evidence of the effect of MRs on mortality or hospital admissions. Aim The aim of this study was to assess the impact of MRs' on hospital admissions and mortality after six and 12 months in a frail population of 369 patients in primary care in a randomized controlled study. Methods Patients were blindly randomized to an intervention group (receiving MRs) and a control group (receiving usual care). Descriptive data on mortality and hospital admissions at six and 12 months were collected. Survival analysis was performed for time to death and time to the first hospital admission within 12 months.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • age>75 years, living in nursing homes or community-dwelling with municipality-provided care, with multi-dose drug dispensing

Exclusion criteria

  • lack of multi-dose drug dispensing, living at home with no municipality-provided care, <75 years old

Treatment and study plan

Medication review

Other

Multi-professional medication review

Primary outcomes

  1. hospital admission

    Time frame: six months

    time to the first hospital admission

  2. hospital admission

    Time frame: twelve months

    time to the first hospital admission

  3. Survival analysis

    Time frame: six months

    time to death

  4. Survival analysis

    Time frame: twelve months

    time to death

Secondary outcomes

  1. number of hospital admissions

    Time frame: six months

    number of hospital admissions

  2. number of hospital admissions

    Time frame: twelve months

    number of hospital admissions

  3. mortality

    Time frame: six months

    number of deaths

  4. mortality

    Time frame: twelve months

    number of deaths

Other outcomes

  1. number of drugs

    Time frame: base-line

    number of drugs

Sponsors and collaborators

Lead sponsor

Region Skane

Other

Registry information

Official study title

The Impact of Medication Reviews Conducted in Primary Care on Hospital Admissions and Mortality - a Randomized Controlled Trial

Important dates

Study start
2011
Primary completion
2018
Study completion
2019
First posted
Aug 1, 2019
Registry last updated
Aug 1, 2019

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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