Medication Regimen Complexity and Glycemic Control in Patients With Diabetes

Polypharmacy is an alarming health issue that is defined as prescription of multiple medications, of which some are redundant or unnecessary. Due to comorbidities, diabetic patients are often prescribed multiple medications. Over prescribing occurs either due to, prescribing medications that are not indicated, continuation of certain medications beyond the time of indication, or prescribing more than one medication with the same effect. Improving glycaemic control is the cornerstone for the prevention and treatment of the diabetic complications.

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Key information

Conditions

Diabetes Mellitus Endocrine System Diseases Glucose Metabolism Disorders Metabolic Diseases Nutritional and Metabolic Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Cairo university hospitals

Cairo, Egypt

About this study

Hypothesis In addition to the side effects and cost of the unnecessary medications, the investigators hypothesis is that poly-pharmacy will adversely affect patients' compliance with the necessary medications.The investigators propose that elimination of unnecessary medications might improve patients' compliance and consequently improve glycemic control diabetic patients.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

All diabetic patients who are eligible by fulfilling all of the following criteria:

HGBA1c ≥7 mg/dl.
2) Poly-pharmacy: defined as the use of five or more medications.
Non- compliance: patients were surveyed with both direct and indirect methods to identify non adherence.

Exclusion criteria

Exclusion after recruitment Any patient whose diabetic medications regimen changed after recruitment due to hospitalisation, illness, stress or patients preference, will be excluded.

Treatment and study plan

Medications review

Other

Medications review. Elimination of all unnecessary prescription to cut down the number of medications to the least possible number.

This is in line with the best practice guidelines.

Primary outcomes

Change in Hemoglobin A1c

Time frame: 3 months

measurement of hemoglobin A1c to determine glycemic control.

Sponsors and collaborators

Lead sponsor

Kasr El Aini Hospital

Other

Registry information

Official study title

Effect of Reducing Medication Regimen Complexity on Glycemic Control in Patients With Diabetes.

Important dates

Study start: 2017
Primary completion: 2017
Study completion: 2017
First posted: Oct 30, 2017
Registry last updated: Sep 5, 2018

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed