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OpenTrials
Completed

NCT Number: NCT05038111

Medical Records Investigation of Whether Perioperative Dexmedetomidine Will Reduce the Duration of Mechanical Ventilation or Hospital Length of Stay in Patients Undergoing Minimally Invasive Cardiac Surgery

The concept of enhanced recovery after surgery (ERAS) is utilizing in multiple specialties widely. Early tracheal extubation is one of the components of ERAS that enhances postoperative recovery and reduces the length of stay in intensive care unit (ICU).Dexmedetomidine is a highly selective, shorter-acting α2-adrenergic receptor agonist that has both analgesic and sedativeeffects.It was associated with decreased mortality, time to extubation, and hospital length of stay in cardiac surgical patients according to previous studies.The purpose of this study was to investigate the effect of perioperative dexmedetomidine on patients undergoing minimally invasive cardiac surgery(MICS) who were early extubated after surgery.

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Key information

Conditions

Mechanical Ventilation Hospital Length of Stay Minimally Invasive Cardiac Surgery

Age range

20 year–99 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Far Eastern Memorial Hospital

New Taipei City, 22061, Taiwan

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patients undergone minimal invasive off-pump coronary artery bypass graft (CABG), valvular surgery or combined procedures at Far Eastern Memorial Hospital, New Taipei City, Taiwan between January 1, 2020 and August 31, 2020.
  • Age above 20 y/o

Exclusion criteria

  • Emergency surgery
  • Postoperative mechanical ventilation more than 6 hours
  • Extubated in the operating room

Treatment and study plan

Dexmedetomidine

Drug

perioperative dexmedetomidine infusion

Primary outcomes

  1. postoperative mechanical ventilation duration

    Time frame: up to 1 week

    from the time the patient arrived at the ICU until extubation

  2. ICU and hospital length of stay

    Time frame: through admission, up to 1 month

Secondary outcomes

  1. postoperative complications

    Time frame: according to ICD 10 on medical record, daily to discharge, up to 1 month

    atrial fibrillation, bradyarrhythmia, myocardial infarction, cerebrovascular accident, acute renal failure and delirium

Sponsors and collaborators

Lead sponsor

Far Eastern Memorial Hospital

Other

Registry information

Important dates

Study start
2021
Primary completion
2021
Study completion
2021
First posted
Sep 8, 2021
Registry last updated
Sep 8, 2021

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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