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NCT Number: NCT02898974

Medical Marijuana and Its Effects on Motor Function in People With Multiple Sclerosis

Medical marijuana is commonly prescribed people with Multiple Sclerosis (MS) for symptom, e.g. spasticity and pain, management. Unfortunately not much is known about its effects outside the treatment for these 2 symptoms. Several previous studies have suggested people with MS using medical marijuana have lower levels of physical disability and improved walking abilities. A major limitation of these previous studies is that the investigators used subjective measures of motor function. In this proposed observational case-control study the investigators plan to objectively measure multiple domains of motor function, such as: fatigue, strength, and walking ability. No marijuana will be brought on to campus or given to participants.

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Key information

Conditions

Multiple Sclerosis Autoimmune Diseases Autoimmune Diseases of the Nervous System Demyelinating Autoimmune Diseases, CNS Demyelinating Diseases Immune System Diseases Nervous System Diseases

Age range

30 year–60 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Department of Health and Exercise Science

Fort Collins, Colorado, 80523, United States

About this study

To investigate the effects of medical marijuana usage on physical function the investigators will employ an observational case-control design. Cases (MS medical marijuana users) will be compared to age, sex, and disease duration matched controls (MS non-cannabis users).

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Medically diagnosed with MS,
  • 30-60 years of age,
  • Moderate disability (Patient Determined Disease Steps score 2-6).

Exclusion criteria

  • Relapse with the last 60 days,
  • High risk for cardiovascular disease (American College of Sports Medicine risk classification),
  • Changes in disease modifying medications within the last 45 days,
  • Concurrent neurological/neuromuscular disease,
  • Hospitalization within the last 90 days,
  • Inability to understand/sign informed consent.

Treatment and study plan

Medical Marijuana

Behavioral

To investigate the effects of medical marijuana usage on physical function we will employ an observational case-control design

Primary outcomes

  1. Fatigue

    Time frame: Through study completion, an average of 6 months.

    Strength decline during fatiguing muscle contraction measured with force transducer

  2. Muscle Strength

    Time frame: Through study completion, an average of 6 months.

    Maximal muscle strength measured with force transducer

  3. Postural Stability

    Time frame: Through study completion, an average of 6 months.

    Timed up and go

Sponsors and collaborators

Lead sponsor

Colorado State University

Other

Collaborators

  • William R. Shaffer, M.D.

Registry information

Official study title

Medical Marijuana and Its Effects on Motor Function in People With Multiple Sclerosis: An Observational Case-control Study

Important dates

Study start
2016
Primary completion
2017
Study completion
2017
First posted
Sep 13, 2016
Registry last updated
Feb 5, 2020

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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