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OpenTrials
Completed

NCT Number: NCT03487354

Medical Abortion With Single Daily Dose of Misoprostol

Medical abortion using multiple vs single daily dose of misoprostol in first trimester miscarriage.

Completed

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Key information

Conditions

Miscarriage Abortion, Spontaneous Female Urogenital Diseases and Pregnancy Complications Pregnancy Complications Urogenital Diseases

Age range

18 year–40 year

Sex eligibility

Female

Study type

Interventional

Phase

Phase 2 / Phase 3

Primary location

Ain Shams University Maternity Hospital

Cairo, Egypt

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Maternal age more than 18 years old (age of legal consent).
  • Gestational age less than 13 weeks.
  • Hemoglobin >10 g/dL.
  • BMI between 25 kg/m2 and 35 kg/m2.
  • Missed abortion.
  • Living fetus with multiple congenital malformations incompatible with life.

Exclusion criteria

  • Maternal age less than 18 years old.
  • Gestational age more than 12 weeks.
  • Hemoglobin <10 g/dL.
  • Anencephaly.
  • Fibroid uterus.
  • BMI less than 25kg/m2 and more than 35kg/m2.
  • Coagulopathy.
  • History or evidence of adrenal pathology.
  • Previous attempts for induction of abortion in the current pregnancy.
  • Allergy to misoprostol or letrozole.
  • Medical disorder that contraindicate induction of abortion (e.g. heart failure).

Treatment and study plan

Misoprostol

Drug

Misoprostol

Primary outcomes

  1. Complete miscarriage

    Time frame: one week

    Assessed by trans-vaginal ultrasound where endometrial thickness less than 15 mm is considered complete miscarriage

Sponsors and collaborators

Lead sponsor

Ain Shams University

Other

Registry information

Official study title

Medical Abortion With Multiple vs Single Daily Dose of Misoprostol in First Trimester Miscarriage: A Randomized Clinical Trial.

Important dates

Study start
2018
Primary completion
2019
Study completion
2019
First posted
Apr 4, 2018
Registry last updated
Jan 29, 2019

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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