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NCT Number: NCT07571395

Median Nerve Electromyography to Monitor Intraoperative Neuromuscular Function

The effect of muscle relaxants need to be followed during surgery and before waking up the patient, the anesthesiologist has to make sure that the effect of muscle relaxants is gone. For this purpose, anesthesiologists use so called objective neurlmuscular monitors. These monitors stimulate the ulnar nerve in the wrist and examine the evoked muscle response. The aim of this study is to examine the usability of another nerve in the wrist, the median nerve.

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Key information

Conditions

Nerve Conduction Study Elective Surgery Neuromuscular Monitoring After Administration of Neuromuscular Blocking Agents in Different Types of Surgery

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

University of Debrecen Medical Center, Department of Anesthesiology and Intensive Care

Debrecen, 4032, Hungary

Location status: Recruiting

Location contact

Reka Nemes, MD PhD

CONTACT

+36309668722

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • ASA I-III physical status
  • elective surgery requiring muscle relaxation
  • both arms are available during surgery in the same position for neuromuscular blockade monitoring
  • signed informed consent form

Exclusion criteria

  • neruomuscular disorder in patient history (eg. stroke, myasthenia)
  • innervation problem in either arms (eg. carpal tunnel syndrome)
  • deformity to either arms (eg. Dupyurten contracture, severe arthritis)
  • Severe hepatic or renal insufficiency that affects muscle relaxant pharmacokinetics
  • skin lesions at the site of electrode placement
  • implanted pacemaker jelenléte
  • gravidity
  • muscle relaxant needs to be repeated during surgery

Treatment and study plan

Electromyography

Diagnostic Test

Electromyographic examination of the median and ulnar nerves to monitor intraoperative neuromuscular blockade

Primary outcomes

  1. CMAP

    Time frame: Baseline

    Comparison of compound muscle action potential amplitudes evoked by median and ulnar nerve stimulation and measured at the thenar

Secondary outcomes

  1. Recovery time

    Time frame: Perioperative

    Time from muscle relaxant administration to spontaneous recovery to TOFR>0,9 monitored with median and ulnar nerve stimulation

  2. Onset time

    Time frame: Baseline

    Time from administration of muscle relaxant to disappearance of twitch response (TOFC0) monitored with median and ulnar nerve stimulation

Other outcomes

  1. Bland-Altman analysis of TOFRs

    Time frame: Intraoperative

    Bland-Altman analysis of TOFRs obtained with medin and ulnar nerve stimulation

  2. Bland-Altman analysis of TOFCs

    Time frame: Intraoperative

    Bland-Altman analysis of TOFCs obtained with median and ulnar nerve stimulation

  3. Bland-Altman analysis of PTCs

    Time frame: Intraoperative

    Bland-Altman analysis of PTCs obtained with median and ulnar nerve stimulation

  4. Baseline TOFRs

    Time frame: Baseline

    Examination of the stability of baseline TOFRs obtained with median and ulnar nerve stabilization

  5. Comparison of CMAP amplitudes obtained from dominant and non dominant hands

    Time frame: Baseline

    Comparison of CMAP amplitudes obtained from dominant and non dominant hands evoked my median and ulnar nerve stimulation

Study contacts

Contact information is provided by the study sponsor or research team.

Reka Nemes, MD PhD

CONTACT

[email protected]

+36 30 966 8722

Sponsors and collaborators

Lead sponsor

Pongrácz Adrienn

Other

Registry information

Official study title

Comparative Examination of Ulnar and Median Nerve Electromyography Examinations to Monitor Intraoperative Neuromuscular Function

Important dates

Study start
2026
Primary completion
2028
Study completion
2028
First posted
May 6, 2026
Registry last updated
Jun 17, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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