Mechanistic Studies of Chronic COPD Using Single-Cell Sequencing and Single-Cell Spatial Transcriptomics

This study is an ambispective cohort study, the sample from patients were from both previously stored and freshly collected . The objective of this study is to investigate the molecular pathological changes underlying the development of chronic obstructive pulmonary disease (COPD). We will use single cell sequencing technology to analyze lung tissue samples from patients who underwent lung resection, with lung tissue from patients without COPD serving as controls. This research aims to provide insights into the pathogenesis of COPD.

Not Yet Recruiting

Trial opening soon.

Get Notified

Key information

Conditions

COPD Chronic Disease Disease Attributes Lung Diseases Lung Diseases, Obstructive Pathologic Processes Pathological Conditions, Signs and Symptoms Pulmonary Disease, Chronic Obstructive Respiratory Tract Diseases

Sex eligibility

All sexes

Study type

Observational

Primary location

Renji Hospital, Shanghai Jiao Tong University School of Medicine

Shanghai, Shanghai Municipality, 200444, China

Location contact

Tang Jiang, Dr

CONTACT

[email protected]

+86 021-86383707

Who can participate

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Receiving lung resection surgery at the hospital for any reason；
Diagnosed with COPD according to the 2024 GOLD guidelines；
Tissue samples that meet collection requirements and are either agreed to be collected or already preserved；

Exclusion criteria

Improper preservation of pathological specimens, refusal to consent to sample collection, or incomplete clinical information；
Combined with other factors causing obstructive airflow limitation;
Diagnosed with asthma according to the GINA 2023 guidelines and with a history of asthma exacerbations within the past year;
Combined with Advanced lung cancer;
Receiving systemic immunosuppressive medications such as anti-rejection drugs;

Treatment and study plan

Primary outcomes

Transcriptomic profile analysis of lung tissues

Time frame: until end of surgery

Study contacts

Contact information is provided by the study sponsor or research team.

Feng Xinyu, Dr

CONTACT

[email protected]

86-17621694653

Sponsors and collaborators

Lead sponsor

Tongji University

Other

Registry information

Official study title

A Bidirectional Cohort Study of Single-Cell Sequencing and Single-Cell Spatial Transcriptomics in Chronic COPD

Important dates

Study start: 2025
Primary completion: 2026
Study completion: 2027
First posted: Oct 6, 2025
Registry last updated: Oct 6, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Not Yet Recruiting