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NCT Number: NCT06951100

Mechanisms of Myocardial Injury and Ischemia in Patients With Rapid Atrial Fibrillation

The goal of this observational study is to better understand the role of measuring troponin (a protein measured by a blood test) and coronary imaging in patients presenting with rapid atrial fibrillation (AF)

The main questions this study aims to answer are:

1. Are patients with a fast, irregular heartbeat (rapid AF) and damage to the heart (myocardial injury) more likely than those without damage to the heart to have blocked heart arteries (obstructive coronary artery disease) 2. Are patients with a fast, irregular heartbeat (rapid AF) and damage to the heart (myocardial injury) with further evidence that their heart hasn't been getting enough oxygen (myocardial ischemia) more likely to have imaging evidence of myocardial infarction than those without myocardial ischemia

To do this, we will measure troponin in patients with rapid AF and then carry out further investigations of the heart (electrocardiogram, echocardiogram, CT scan and cardiac MRI)

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Key information

Conditions

Atrial Fibrillation (AF) Arrhythmias, Cardiac Arterial Occlusive Diseases Arteriosclerosis Atrial Fibrillation Cardiovascular Diseases Coronary Artery Disease Coronary Disease Heart Diseases Infarction Ischemia Myocardial Infarction Myocardial Ischemia Necrosis Pathologic Processes Pathological Conditions, Signs and Symptoms Vascular Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Royal Infirmary of Edinburgh

Edinburgh, East of England, United Kingdom

Location status: Recruiting

Location contact

Elizabeth Highton-Williamson

CONTACT

[email protected]

0131 242 6431

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Age 18 years and over
  • Primary presentation with symptoms related to atrial fibrillation
  • Atrial fibrillation with a ventricular rate >100 bpm on a 12-lead electrocardiogram
  • Able to provide informed consent

Exclusion criteria

  • Previous myocardial infarction
  • Previous coronary revascularisation procedure
  • Patients in renal failure (eGFR <30ml/min/1.73m2) or major allergy to contrast media
  • Pregnancy or breast feeding
  • Deemed unsuitable for participation in the study by the attending clinician
  • Previous enrolment in the trial

Treatment and study plan

CT Coronary Angiography

Diagnostic Test

To assess the presence of obstructive coronary artery disease, participants will either have coronary angiography as part of their routine care or they will return for a research CT scan of their heart (CT Coronary Angiogram)

Primary outcomes

  1. Presence of obstructive coronary artery disease

    Time frame: within 4 weeks of presentation

    Presence of obstructive coronary artery disease as defined as at least one stenosis ≥70% in a major epicardial coronary artery or ≥50% in the left main stem on CTCA or invasive coronary angiography

Secondary outcomes

  1. Imaging evidence of new myocardial infarction

    Time frame: within 4 weeks of presentation

    Imaging evidence of new myocardial infarction

Sponsors and collaborators

Lead sponsor

University of Edinburgh

Other

Collaborators

  • British Heart Foundation
  • NHS Lothian

Registry information

Acronym: Mi-AF

Important dates

Study start
2025
Primary completion
2026
Study completion
2029
First posted
Apr 30, 2025
Registry last updated
Jun 15, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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