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OpenTrials
Completed

NCT Number: NCT00152724

Mechanisms of Human Cutaneous Microcirculation in Healthy Volunteers

Microvascular dysfunctions are critical events in several diseases including diabetes. This study will develop a methodology for microvascular investigation in human skin. The purpose of the study is to investigate the physiological response of the cutaneous microcirculation to physical, thermal, mechanical or chemical stimulations.

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Key information

Conditions

Healthy Volunteers

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Laboratoire de Physiologie et Explorations Vasculaires - CHU Angers

Angers, 49033, France

About this study

This study has investigated various aspects of the physiology of the microcirculation in the past years and is still recruiting under parallel protocols of physiological investigations of the neurovascular control of the cutaneous microcirculation.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Healthy volunteers with no clinical signs of, or risk factors for, vascular disease

Exclusion criteria

  • Smokers, Pregnancy, Allergy,

Treatment and study plan

pressure strain system, iontophoresis

Device

scopolamin

Drug

EMLA

Drug

Capsaicin

Drug

Aspirin

Drug

clopidogrel

Drug

Celecoxib

Drug

Indomethacin

Drug

Acetylcholine

Drug

Sodium Nitroprusside

Drug

brethyllium

Drug

general and local heating

Device

Primary outcomes

  1. Amplitude of the vasomotor response to stimuli

    Time frame: 1 hour

Secondary outcomes

  1. Kinetics of the vasomotor response to stimuli

    Time frame: 1 hour

Sponsors and collaborators

Lead sponsor

University Hospital, Angers

Other Gov

Registry information

Official study title

Etude de la Reserve Vasomotrice Microcirculatoire cutanée

Important dates

Study start
1996
Primary completion
2008
Study completion
2008
First posted
Sep 9, 2005
Registry last updated
Nov 1, 2017

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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