Mechanisms of Exercise-Induced Hypoalgesia

Exercise-Induced Hypoalgesia (EIH) is a lessening of pain sensitivity in response to an acute bout of exercise. Limited research has examined the effects of expectations on EIH during a dynamic resistance training during different intensities. Therefore, the purpose of this study is to examine the effects of positive and negative expectations on EIH.

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Key information

Conditions

Healthy

Age range

18 year–60 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

University of Central Florida

Orlando, Florida, 32765, United States

About this study

Individuals who meet the eligibility criteria and consent to participate will attend one testing session that is approximately one hour. Baseline Pressure Pain Threshold will be measured followed by random assignment to one of four study arms.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Pain Free

Exclusion criteria

Non-English speaking
Regular use of prescription pain medications
Current or history of chronic pain condition
Currently taking blood-thinning medication
Any blood clotting disorder, such as hemophilia
Systemic medical condition known to affect sensation, such as uncontrolled diabetes or neurological conditions
Not physically ready to exercise without a medical exam as indicated by the Physical Activity Readiness Questionnaire Plus (PAR-Q+)
Not have had Surgery, injury, or fracture within the past 6 months

Treatment and study plan

Positive Expectations Instructional Set

Other

Participants randomly assigned to this instructional set will be told, "You will be completing an intervention known to be effective for some people with shoulder pain. We expect this will make you less sensitive to the pressure applied to your shoulder and thigh and you will require more pressure than what was previously necessary to experience pain."

Negative Expectations Instructional Set

Other

Participants randomly assigned to this instructional set will be told, "You will be completing an intervention which is not effective for some people with shoulder pain. We expect this will make you more sensitive to the pressure applied to your shoulder and thigh and you will require less pressure than what was previously necessary to experience pain."

Primary outcomes

Pressure Pain Threshold

Time frame: Change from baseline immediately after exercise

Pressure Pain Threshold will be applied with a digital algometer before and after the exercise intervention.

Sponsors and collaborators

Lead sponsor

University of Central Florida

Other

Registry information

Important dates

Study start: 2023
Primary completion: 2024
Study completion: 2024
First posted: Sep 22, 2023
Registry last updated: Apr 22, 2024

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed