Skip to main content
OpenTrials
Completed

NCT Number: NCT02311075

Mechanisms of Endothelial Dysfunction in Type 2 Diabetes

Endothelial dysfunction of conduit arteries plays an important role in the development of cardiovascular complications associated with type 2 diabetes. In order to propose targeted therapeutic approaches, this study aim to determine the mechanisms involved in endothelial dysfunction of conduit arteries in these patients.

Completed

Looking for future studies?

Notify Me

Key information

Conditions

Diabetes Mellitus, Type 2 Diabetes Mellitus Endocrine System Diseases Glucose Metabolism Disorders Metabolic Diseases Nutritional and Metabolic Diseases

Age range

30 year–70 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Rouen University Hospital

Rouen, 76031, France

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Type 2 diabetic patients or control subjects or healthy volunteers

Exclusion criteria

  • Macroangiopathy
  • Insulin treatment
  • Chronic kidney disease (eGFR<60 ml/min/m²)
  • Hyperlipidemia (total cholesterol>2.5 g/l)
  • Smoking habit > 5 cigarettes/day
  • Pregnancy

Treatment and study plan

blood samples

Biological

Blood samples will be performed at baseline and during endothelial stimulation by hand skin heating to quantify metabolites of NO, EETs, ET-1 and ROS

Primary outcomes

  1. Change from Baseline in EET concentration during endothelial stimulation

    Time frame: 30 min from the beginning of hand skin heating

Secondary outcomes

  1. Change from Baseline in NO concentration during endothelial stimulation

    Time frame: 30 min from the beginning of hand skin heating

  2. Change from Baseline in ET-1 concentration during endothelial stimulation

    Time frame: 30 min from the beginning of hand skin heating

  3. Change from Baseline in ROS concentration during endothelial stimulation

    Time frame: 30 min from the beginning of hand skin heating

Sponsors and collaborators

Lead sponsor

University Hospital, Rouen

Other

Registry information

Official study title

Determination of the Mechanisms Involved in Conduit Artery Endothelial Dysfunction in Type 2 Diabetes

Acronym: DIAB-EETs

Important dates

Study start
2014
Primary completion
2016
Study completion
2016
First posted
Dec 8, 2014
Registry last updated
Jun 14, 2017

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Related clinical trials

Published trials that share one or more normalized conditions with this study.