Mechanisms of Anaphylaxis

The purpose of this study is to explore different mechanisms for anaphylaxis and find novel biomarkers for this hypersensitivity syndrome. The study participants are patients with anaphylaxis, patients with mild allergic reactions, and patients with febrile transfusion reactions. The investigators will also include a group of healthy controls.

Active, Not Recruiting

This study is active but is not currently recruiting participants.

Key information

Conditions

Anaphylaxis Allergy Febrile Transfusion Reaction Hematologic Diseases Hemic and Lymphatic Diseases Hypersensitivity Hypersensitivity, Immediate Immune System Diseases Transfusion Reaction

Age range

16 year–120 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Haukeland University Hospital

Bergen, Norway

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

According to the specific cohort:

Diagnosis of anaphylaxis
Mild allergic reaction
Febrile transfusion reaction
Healthy, no known allergic disease

Exclusion criteria

Suspicion or diagnosed sepsis Children

Treatment and study plan

Biomarkers (platelet activating factor [PAF], anaphylatoxins) and basophil activation test (BAT)

Diagnostic Test

Analysis of biomarkers and basophil activation test

Primary outcomes

Clarify mechanisms for anaphylaxis and establish biomarkers for this syndrome

Time frame: 2 days

Immunological/nonimmunological mechanism

Sponsors and collaborators

Lead sponsor

Haukeland University Hospital

Other

Registry information

Acronym: ANAMEK

Important dates

Study start: 2017
Primary completion: 2026
Study completion: 2026
First posted: Jun 9, 2017
Registry last updated: Aug 3, 2022

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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