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OpenTrials
Completed

NCT Number: NCT01708096

Mechanisms Behind Antidiabetic Effects by Gastric By-pass

The aim of the study is to develop new strategies in treatment of continuous increasing number of patients with type 2 diabetes by understanding how bariatric surgery cures or improves this condition.

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Key information

Conditions

Diabetes Mellitus Typ 2 and Obesity Body Weight Nutrition Disorders Nutritional and Metabolic Diseases Obesity Overnutrition Overweight Pathological Conditions, Signs and Symptoms Signs and Symptoms

Age range

18 year–70 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Karolinska Institutet, Stockholm, Stockholm County Council, Sweden

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Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Diabetes typ 2
  • 18-70 years
  • BMI > 35 kg/m2
  • Treated with oral antidiabetic agents and/or insulin
  • laparoscopic surgery

Exclusion criteria

  • Pharmacological treatment (other then above) witch could affect glucose metabolism
  • open surgery

Treatment and study plan

Modifast

Dietary Supplement

2 weeks before gastric by-pass patients are treated with VLD, 1000 kcal/day

Normal diet

Dietary Supplement

normal diet 2 weeks before gastric by-pass

Primary outcomes

  1. Insulin sensitivity

    Time frame: 12-18 month after gastric bypass

    Insulin sensitivity measured by hyperinsulinemic normoglycemic clamp technique

Secondary outcomes

  1. Weight reduction

    Time frame: 12-18 month after gastric bypass

Other outcomes

  1. Insulin signaling and glucose transport in skeletal muscle

    Time frame: 12-18 month after gastric by-pass

Sponsors and collaborators

Lead sponsor

Karolinska Institutet

Other

Collaborators

  • Uppsala University Hospital

Registry information

Important dates

Study start
2009
Primary completion
2013
Study completion
2013
First posted
Oct 16, 2012
Registry last updated
Mar 12, 2014

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

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This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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