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NCT Number: NCT02171845

Mechanisms and Factors Responsible for the Inhibition of Transposons During Fetal Gonad Development in Humans

This is a single-centre study over 36 months for the inclusion of 30 patients. The selection and inclusion of patients will take place according to the criterion of Medical Termination of Pregnancy at 4 different gestational ages (8-12 weeks of gestation (WG)), 13-16 WG, 17-23 WG and 25-35 WG. The tissue analysed will principally be the gonads, other somatic tissue will also be systematically harvested in parallel (liver and psoas muscle) for control purposes. The gonads will be subjected to molecular biology analyses destined to quantify the expression of transposons and their inhibitors.

Recruiting

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Key information

Conditions

Medical Termination of Pregnancy Voluntary Termination of Pregnancy

Age range

10 week–37 week

Sex eligibility

Male

Study type

Observational

Primary location

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Couple or mother who has provided written informed consent
  • Foetus between 10 and 37 weeks of amenorrhea (WA)
  • Male foetus
  • Foetus obtained following medical termination of pregnancy or voluntary termination of pregnancy

Exclusion criteria

  • persons without national health insurance cover
  • foetus presenting aneuploidy
  • foetus presenting a malformation of the genital organs

Treatment and study plan

surgical biopsies

Other

Primary outcomes

  1. Spatio-temporal analysis of the activity of TEs by RT-qPCR and immunostaining

    Time frame: Baselines

Secondary outcomes

  1. Promoter methylation profile by pyrosequencing

    Time frame: Baselines

Other outcomes

  1. Spatiotemporal analysis piARN way: RT qPCR, Small RNA Seq, and immunoprecipitation of proteins PIWI

    Time frame: Baselines

Study contacts

Contact information is provided by the study sponsor or research team.

Patricia FAUQUE

CONTACT

[email protected]

3.80.29.50.31 ext. +33

Sponsors and collaborators

Lead sponsor

Centre Hospitalier Universitaire Dijon

Other

Registry information

Important dates

Study start
2014
Primary completion
2027
Study completion
2027
First posted
Jun 24, 2014
Registry last updated
Jul 8, 2022

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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