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OpenTrials
Completed

NCT Number: NCT06031675

Mechanism for Exercise to Delay Cardiac Aging

The goal of this clinicaltrial is to assess and compare isokinetic performance, surface electromyography, laboratory parameters, and cardiorespiratory function both before and after engaging in vigorous intermittent lifestyle physical activity(VILPA) within a healthy population.

The main question it aims to answer is:

[1] Does VILPA yield effective outcomes?

Throughout the course of the trial, participants will engage in a simulated regimen of vigorous intermittent lifestyle physical activity for a duration of 8 weeks. The efficacy of the exercise protocol will be quantified and evaluated through the utilization of a wearable device.

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Key information

Conditions

Activity, Motor Behavior Health Behavior Motor Activity

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Guangdong Pharmaceutical University

Guangzhou, Guangdong, 510006, China

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Healthy Adults
  • No exercise habits (more than 3 months)

Exclusion criteria

  • Exercising ≥ 3 times per week;
  • the presence of chronic diseases, such as hypertension, hyperglycemic states, etc;
  • have conducted an exercise program in the past three months.

Treatment and study plan

Vigorous intermittent lifestyle physical activity

Other

The specific exercise regimen involves performing rope jumping activities three times a day, with each session aimed at surpassing the exercise threshold (not conducted in a continuous manner), where the heart rate should exceed 160 beats per minute. This routine will be undertaken five times a week, continuously for a span of 8 weeks.

Primary outcomes

  1. Isometric Strength Test

    Time frame: 15 minutes

    Isokinetic muscle strength testing with the Isomed 2000

  2. Surface electromyography

    Time frame: 30 minutes

  3. Exercise Flat Test

    Time frame: 30 minutes

    cardiopulmonary function

Secondary outcomes

  1. Fasting glucose

    Time frame: 5 minutes

  2. Blood lipid

    Time frame: 5 minutes

Sponsors and collaborators

Lead sponsor

Xiao-dong Zhuang

Other

Registry information

Official study title

The αKlotho Protein-mediated NLRP3/Caspase-1/GSDMD Pathway Counteracts Myocardial Stunning: a Novel Mechanism for Exercise to Delay Cardiac Aging

Important dates

Study start
2023
Primary completion
2023
Study completion
2023
First posted
Sep 11, 2023
Registry last updated
Sep 11, 2023

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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