Measuring Time Windows in Patients With Schizophrenia and Healthy Controls

Abnormalities in the ability to distinguish events in time may have a great impact on everyday life. The main objective of the study is to evaluate the magnitude of the temporal windows in schizophrenia, i.e. the time interval during which two events are perceived as synchronous. The investigators test the hypothesis that these temporal windows are enlarged, and check the relationship between this impairment and disorganization symptoms, in order to explore the link between this cognitive impairment and clinical symptoms. They explore also the neurobiological bases of the impairment by means of electroencephalogram (EEG) recordings. Event-related potentials (N50) will reveal whether or not the coding of the stimuli has the same temporal characteristics in patients and controls. The distribution and amplitude of oscillatory activities will be analyzed as a function of the synchronous or asynchronous response of the subject, thus allowing to explore the links between synchrony perception and neuronal synchronization phenomena.

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Key information

Conditions

Schizophrenia Mental Disorders Schizophrenia Spectrum and Other Psychotic Disorders

Age range

18 year–50 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Service de Psychiatrie Adulte & INSERM U841, Hôpital Albert Chenevier et Henri Mondor (AP-HP), Créteil, France

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Patients with schizophrenia (DSM-IV criteria)
Healthy controls matched with patients on age, sex and education level
Age between 18 and 50
Informed consent signed
No severe somatic illness
No invalidating sensory disease
No drug abuse, as defined by DSM-IV criteria
No general anesthesia in the past 3 months
No intake of drug affecting the CNS, except for patients

Treatment and study plan

EEG

Procedure

One 20 minutes session

Sponsors and collaborators

Lead sponsor

University Hospital, Strasbourg, France

Other

Collaborators

Centre National de la Recherche Scientifique, France
Institut National de la Santé Et de la Recherche Médicale, France
Institut de Physique Biologique de Strasbourg

Registry information

Official study title

Relating the 'Experienced Present' With the Mechanisms of Neuronal Function: A Comparative Study in Patients With Schizophrenia and Healthy Controls Using Psychophysical and Neurophysiological Methods

Important dates

Study start: 2005
Primary completion: 2012
Study completion: 2012
First posted: Jul 11, 2006
Registry last updated: Oct 5, 2017

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed