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OpenTrials
Completed

NCT Number: NCT01792154

Measuring Corneal Cells With Specular Microscopy

Assess changes in the corneal cell count using Specular Microscopy following tretments with Anti-VEGF injections

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Key information

Conditions

Retinal Diseases Eye Diseases

Age range

50 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Retina Institute of Hawaii

Honolulu, Hawaii, 96815, United States

About this study

Patients with active Wet AMD often receive intraocular Anti-VEGF injections such as Macugen, Lucentis and Avastin on a monthly basis for an extended period of time. While these medications are very effective at controlling the Choroidal Neovascularization associated with this disease, the impact of monthly intravigtreal Anti-VEGF injections on the viability of corneal endothelial cells has yet to be fully characterized. The availability of CESM as a diagnostic test that can be performed quickly and painlessly in the clinic offers a method of tracking corneal endothelial cell count in this patient population.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Wet Age-related Macular Degeneration
  • Receiving monthly intraocular injections of Anti-VEGF medication for at least 3 months
  • Age greater than 50 years of age

Exclusion criteria

  • experiences adverse events

Treatment and study plan

Primary outcomes

  1. Specular Photomicrographic Assessment of the Effect of Anti-VEGF Intravitreal injections on corneal thickness and endothelial cell density and morphology

    Time frame: Baseline, Month 6 and Month 12

    Changes in corneal endothelial cell density and corneal thickness measured by changes in pachymetry and corneal cell count.

Sponsors and collaborators

Lead sponsor

Retina Institute of Hawaii

Other

Registry information

Official study title

Specular Photomicrograpic Assessment of the Effect of Anti-VEGF Intravitreal Injections on Corneal Thickness and Endothelial Cell Density and Morphology

Important dates

Study start
2012
Primary completion
2012
Study completion
2012
First posted
Feb 15, 2013
Registry last updated
Feb 15, 2013

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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