Skip to main content
OpenTrials
Not Yet Recruiting

NCT Number: NCT07558473

Measuring Brain Changes Following Cognitive Intervention in Pediatric Patients With Brain Tumors

The goal of this study is to learn if an online computerized training program improves processing speed in children with pediatric brain tumors. The main questions it aims to answer are:

1. Is the cognitive intervention feasible to administer to children with brain tumors during and after cancer treatment? 2. Is the cognitive intervention acceptable to patients and caregivers? 3. Does the cognitive intervention improve neuropsychological functioning?

There is no comparison group for this study.

Participants will:

1. Complete 15 minutes of online computerized cognitive training 5 times a week for 8 weeks. 2. Have weekly check-ins with the cognitive coach. 3. Fill out acceptability surveys at the end of the cognitive intervention. 4. Complete pre- and post- neuropsychological testing.

Not Yet Recruiting

Trial opening soon.

Get Notified

Key information

Conditions

Brain Tumor, Pediatric Brain Diseases Brain Neoplasms Central Nervous System Diseases Central Nervous System Neoplasms Neoplasms Neoplasms by Site Nervous System Diseases Nervous System Neoplasms

Age range

Up to 25 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Kennedy Krieger Institute

Baltimore, Maryland, 21205, United States

Location contact

Emily J Amsden, BS

CONTACT

[email protected]

215-316-2343

Rachel K Peterson, PhD

PRINCIPAL_INVESTIGATOR

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patients with a primary tumor located in the brain
  • Diagnosed between 0 and 25 years of age
  • Within five years of cancer diagnosis
  • Receiving care at Johns Hopkins Hospital

Exclusion criteria

  • Patients with a primary tumor outside of the brain

Treatment and study plan

Online computerized cognitive training intervention focused on processing speed.

Behavioral

This online cognitive intervention aims to improve processing speed through individualized, computerized cognitive exercises. A cognitive coach selects a set of cognitive exercises for each participant based on identified needs, cognitive ability, and age. Participants complete 15 minutes of training, 5 times per week for 8 weeks, for a target total of approximately 10 hours of training.

Primary outcomes

  1. Platform Engagement - Logins

    Time frame: 8 weeks

    Total number of logins recorded over the intervention period.

  2. Platform Engagement - Task Completion

    Time frame: 8 weeks

    Total number of completed cognitive training levels

  3. Engagement Barriers

    Time frame: Weekly during 8-week intervention

    Participant-reported engagement and barriers measured using a Likert-scale questionnaire administered weekly during the intervention. Mean total score will be reported. Qualitative feedback regarding barriers and facilitators to engagement will also be collected to provide descriptive context.

  4. Acceptability

    Time frame: Week 8

    Participant-reported acceptability measured using a Likert-scale questionnaire administered at the end of the intervention. Mean total score will be reported. Qualitative feedback regarding participant experience will also be collected to provide descriptive context.

Secondary outcomes

  1. Performance-based Cognitive Functioning

    Time frame: Prior to the intervention, immediately following intervention, and 6 months after intervention completion.

    Changes in processing speed as measured by the NIH toolbox.

  2. Parent and Self-report Measures of Cognitive Functioning

    Time frame: Prior to the intervention, immediately following intervention, and 6 months after intervention completion.

    Change in cognitive functioning as measured by the PROMIS Cognitive Function Child and Parent Proxy surveys

Study contacts

Contact information is provided by the study sponsor or research team.

Emily J Amsden, BS

CONTACT

[email protected]

215-316-2343

Sponsors and collaborators

Lead sponsor

Hugo W. Moser Research Institute at Kennedy Krieger, Inc.

Other

Registry information

Important dates

Study start
2026
Primary completion
2031
Study completion
2033
First posted
Apr 30, 2026
Registry last updated
Jun 26, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Related clinical trials

Published trials that share one or more normalized conditions with this study.