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NCT Number: NCT02627157

Measurements of Corneal Biomechanical Properties Using a Dynamic Scheimpflug Analyzer for Young Healthy Adults in South Korea

The human cornea is affected by the magnitude and velocity of both internal and external forces because the cornea has both static and dynamic resistance components. Considering these natures of the human cornea, many investigators have tried to demonstrate corneal biomechanical properties to understand these characteristics of the cornea. Corneal biomechanical properties are known to influence the accuracy of measurements in intraocular pressure (IOP) and are recognized as important factor to explain the susceptibility of development of glaucomatous damage. Until recently, the only instrument which enabled the in vivo measurements of the ocular biomechanical properties was ocular response analyzer (ORA, Reichert Ophthalmic Instruments, Depew, NY, USA).8 The ORA has been used to assess the biomechanical properties of the cornea according to the dynamic bidirectional applanation process. A dynamic Scheimpflug analyzer (corneal visualization Scheimpflug technology [Corvis ST], OCULUS, Wetzlar, Germany) has been introduced recently and has become a useful instrument for evaluating corneal biomechanical properties. The dynamic Scheimpflug analyzer captures the dynamic process of corneal deformation caused by an air puff using an ultra-high-speed Scheimpflug camera at a rate of up to 4,330 images per second. Until now, well-organized analysis on the normative data of the corneal biomechanical profiles measured with the dynamic Scheimpflug analyzer for young healthy adults has not been reported yet. Hence, in the present study, we aim to conduct normative data analysis for the corneal biomechanical properties with the dynamic Scheimpflug analyzer in a cohort of young healthy adults in South Korea.

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Key information

Conditions

Myopia Eye Diseases Refractive Errors

Age range

20 year–40 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Institute of Vision Research, Department of Ophthalmology, Yonsei University College of Medicine

Seoul, 102-752, South Korea

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Participants will be included in analyses if they are 20 to 40 years of age
  • Participants who have myopia with a spherical equivalent (SE) between 0.00 and -11.00 diopters (D)

Exclusion criteria

  • Participants will be excluded from analyses if they had previous ocular or intraocular surgery, a visual field defect, suspicious optic disc appearance, IOP ≥ 30 mmHg, or presence of corneal abnormalities such as keratoconus and forme fruste keratoconus, corneal scarring that would preclude accurate measurements.

Treatment and study plan

Dynamic Scheimpflug Analyzer

Device

Measurements of Corneal Biomechanical Properties Using a Dynamic Scheimpflug Analyzer

Primary outcomes

  1. applanation time (AT)

    Time frame: 1 hour

  2. applanation length (AL)

    Time frame: 1 hour

  3. corneal velocity (CV)

    Time frame: 1 hour

  4. deformation amplitude

    Time frame: 1 hour

  5. peak distance

    Time frame: 1 hour

  6. radius

    Time frame: 1 hour

  7. maximal concave power

    Time frame: 1 hour

  8. central corneal thickness (CCT)

    Time frame: 1 hour

  9. intraocular pressure (IOP)

    Time frame: 1 hour

Sponsors and collaborators

Lead sponsor

Yonsei University

Other

Registry information

Important dates

Study start
2015
Primary completion
2016
Study completion
2016
First posted
Dec 10, 2015
Registry last updated
Jan 22, 2019

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

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This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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