Skip to main content
OpenTrials
Recruiting

NCT Number: NCT07494890

Measurement Properties of Mechanical Cost of Walking for Individuals With Walking Impairment

Walking impairment following neurologic injury can increase the energy cost of walking threefold, acting as a functional barrier to independence. The goal of this cross-sectional study is to determine the measurement properties of a novel biomechanical cost of walking measure in chronic stroke capable of pinpointing the origins of movement inefficiencies. This research aims to:

1. determine the convergent validity of biomechanical cost of walking with functional measures in relation to metabolic cost of walking, 2. determine the reliability of biomechanical cost of walking in relation to metabolic cost of walking, 3. determine the responsiveness of biomechanical cost of walking in relation to metabolic cost of walking.

Individuals with walking impairment from stroke will complete three 5-minute comfortable speed treadmill walking trials. The 3rd walking trial will be against resistance to increase cost of walking. This single session study will compare the metric properties of biomechanical cost of walking in relation to metabolic cost of walking.

Recruiting

Interested in participating?

Request Info

Key information

Age range

30 year–80 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

University of Cincinnati - Digital Futures

Cincinnati, Ohio, 45206, United States

Location status: Recruiting

Location contact

Christina Garrity, DPT

CONTACT

[email protected]

(513) 558-7499

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Age 30-80 years at the time of consent
  • Hemiparesis from ischemic and/or hemorrhagic strokes
  • Most recent stroke for which participant sought treatment, at least 3 months prior to study consent
  • Walking speed <1.0 m/s on the 10-meter walk test
  • Able to walk 10m over ground with assistive devices as needed
  • Able to walk at least 5 minutes continuously on the treadmill ≥ 0.1 mile per hour
  • No contraindications to exercise according to ACSM guidelines
  • Able to communicate with investigators, follow a 2-step command and correctly answer consent comprehension questions

Exclusion criteria

  • Hospitalization for cardiac or pulmonary disease within past 3 months
  • Implanted pacemaker or defibrillator
  • Severe lower limb hypertonia (Ashworth >2)
  • Foot drop or lower limb joint instability without adequate stabilizing device
  • Clinically significant neurologic disorder other than stroke
  • Other significant medical condition likely to jeopardize safety (e.g. joint contracture, gait limited by pain)
  • Pregnancy

Treatment and study plan

Resisted walking

Behavioral

Comfortable speed treadmill walking with resisted forward progression.

Primary outcomes

  1. Constituent Lower Extremity Work

    Time frame: 1st minute and 5th minute of resisted walking trial versus non-resisted walking trial.

    Energy expenditure calculated using biomechanical variables such as force and limb motion

  2. Metabolic Cost of Walking

    Time frame: 1st minute and 5th minute of resisted walking trial versus non-resisted walking trial.

    Energy expenditure calculated using oxygen consumption and carbon dioxide production

Study contacts

Contact information is provided by the study sponsor or research team.

Christina Garrity, DPT

CONTACT

[email protected]

(513) 558-7499

Sponsors and collaborators

Lead sponsor

University of Cincinnati

Other

Registry information

Important dates

Study start
2026
Primary completion
2027
Study completion
2027
First posted
Mar 27, 2026
Registry last updated
Jul 6, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.