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Completed

NCT Number: NCT00783029

Measurement of the Eye's Blood Vessels Using the Dynamic Vessel Analyzer (DVA)

The purpose of this research study is examine the response of the blood vessels in the eye to a light flicker stimulus using the Dynamic Vessel Analyzer (DVA) on two separate days in healthy individuals. The DVA uses an instrument which is used during routine eye examinations. The hypothesis of the study is that the changes in eye's blood vessel will be similar between the two visits; thus establishing reproducibility of the measurements for future comparisons to individuals with stroke or heart disease. In addition, this study will compare the eye's blood vessel responses to responses of the blood vessels in the arm using Doppler ultrasound.

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Key information

Conditions

Healthy Aneurysm Cardiovascular Diseases Vascular Diseases

Age range

21 year–65 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Penn State Milton S. Hershey Medical Center

Hershey, Pennsylvania, 17033, United States

About this study

Retinal blood vessels have been suggested to be an index of the cerebral and coronary microvasculature function. Since the retinal vessels are not under direct sympathetic control, this vascular bed is an ideal location to examine local mechanisms of vascular regulation(i.e. metabolite/endothelial and myogenic). Based on previously published data on animal and human responses, the central purpose for the proposed research is to compare the retinal and brachial vasodilatation responses in healthy subjects using the Dynamic Vessel Analyzer (DVA). Our rationale for this proposal is to better understand retinal blood flow in healthy individuals, gain insight into vascular reactivity in different vascular beds, and lastly to establish standards and reproducibility of DVA Measurements.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Healthy Individuals
  • Age: 21 to 65 years
  • Non-smokers
  • Non-obese

Exclusion criteria

  • History of cardiovascular, pulmonary, peripheral vascular disease, renal, prostate, and urinary retention disease; Hypertension; Narrow angle Glaucoma or Age Related Macular Degeneration.
  • Pregnancy
  • Inability to fixate using eye device
  • Does not wish to participate

Treatment and study plan

Primary outcomes

  1. To characterize changes in the diameter of retinal blood vessels to a light-induced flicker stimulus in healthy subjects on two separate visits.

    Time frame: 1 Year

Secondary outcomes

  1. To compare retinal vasodilator responses to brachial reactive hyperemic responses.

    Time frame: 1 Year

Sponsors and collaborators

Lead sponsor

Penn State University

Other

Registry information

Official study title

Reproducibility of Dynamic Vessel Analyzer Measurements and Establishment of Standards

Important dates

Study start
2008
Primary completion
2011
Study completion
2011
First posted
Oct 31, 2008
Registry last updated
Feb 7, 2012

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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